Dr Samadhi Silva
Academic and research departments
School of Chemistry and Chemical Engineering, Faculty of Engineering and Physical Sciences.About
My research project
Computational modelling of the effect of product formulations on skin penetrationInvestigating skin penetration is very important in many aspects and many researchers have paid their attention in this area. Product formulations is one of the main factors that has a huge effect on skin penetration. Although many experimental approaches are taken to investigate this area, computational modelling is very important in predicting and analysing skin penetration considering time and cost.
To analyse thermodynamic property variations in different formulations and investigate how these variations affect the skin penetration of ingredients is one of the main aims of this project. Skin penetration is modelled through MATLAB. Evaporation is one of the main factors that changes the formulation. Evaporation is modelled starting with basic principles and that model is combined with skin penetration model to analyse the effect of evaporation on skin penetration. Further, other factors of the formulation that can affect the skin penetration such as pH, viscosity and penetration enhancement will also be investigated in the project.
Research Theme : Formulation and Products
Supervisors
Investigating skin penetration is very important in many aspects and many researchers have paid their attention in this area. Product formulations is one of the main factors that has a huge effect on skin penetration. Although many experimental approaches are taken to investigate this area, computational modelling is very important in predicting and analysing skin penetration considering time and cost.
To analyse thermodynamic property variations in different formulations and investigate how these variations affect the skin penetration of ingredients is one of the main aims of this project. Skin penetration is modelled through MATLAB. Evaporation is one of the main factors that changes the formulation. Evaporation is modelled starting with basic principles and that model is combined with skin penetration model to analyse the effect of evaporation on skin penetration. Further, other factors of the formulation that can affect the skin penetration such as pH, viscosity and penetration enhancement will also be investigated in the project.
Research Theme : Formulation and Products
University roles and responsibilities
- Foundation year laboratory demonstrator
- Tutor of Engineering systems and dynamics module
- Co-supervisor of Master’s students research projects
My qualifications
ResearchResearch interests
My main research interests are as follows
- Computational modelling of dermal absorption kinetics
- Computational modelling of evaporation from product formulations
- Computational modelling of solubility variations of product formulations
- Modelling the effect of penetration enhancement on skin penetration
Research interests
My main research interests are as follows
- Computational modelling of dermal absorption kinetics
- Computational modelling of evaporation from product formulations
- Computational modelling of solubility variations of product formulations
- Modelling the effect of penetration enhancement on skin penetration
Publications
Purpose: Volatiles are common in personal care products and dermatological drugs. Determining the impact of evaporation of volatiles on skin permeation is crucial to evaluate and understand their delivery, bioavailability, efficacy and safety. We aim to develop an in-silico model to simulate the impact of evaporation on the dermal absorption of volatiles.
Method: The evaporation of volatile permeants was modelled using vapour pressure as the main factor. This model considers evaporation as a passive diffusion process driven by the concentration gradient between the air-vehicle interface and the ambient environment. The evaporation model was then integrated with a previously published physiologically based pharmacokinetic (PBPK) model of skin permeation and compared with published in vitro permeation test data from the Cosmetics Europe ADME Task Force.
Results: The evaporation-PBPK model shows improved predictions when evaporation is considered. In particular, good agreement has been obtained for the distributions in the evaporative loss, and the overall percutaneous absorption. The model is further compared with published in-silico models from the Cosmetics Europe ADME Task Force where favourable results are achieved.
Conclusion: The evaporation of volatile permeants under finite dose in vitro permeation test conditions has been successfully predicted using a mechanistic model with the intrinsic volatility parameter vapour pressure. Integrating evaporation in PBPK modelling significantly improved the prediction of dermal delivery.