AMR-detecting wound sensors: sensor arrays to diagnose beta-lactamase activity in a wound

Anti-microbial resistance (AMR) remains one of the greatest threats to humanity. Chronic wounds are defined as wounds that exceed a 3-month healing process and do not show a timely improvement during treatment. Chronic wounds can become colonised with bacteria (including antimicrobial-resistant bacteria) and this critical colonisation can result, if left untreated, in wound infection. Wound infection and its persistence are widely considered a major contributor to chronicity, with bacterial biofilms being responsible for over 80% of persistent infections and with many exhibiting genetic AMR. 

β-lactam antibiotics, such as penicillins and cephalosporins, are key front-line treatments for infections; however, bacteria have evolved to produce antibiotic inactivating enzymes, such as β-lactamases. β-Lactamase enzymes are the leading cause of antibiotic resistance, and these enzymes hydrolyse the β-lactam ring present in this class of antibiotics preventing the antibiotics’ ability to kill its target bacteria. This project aims to use electrochemical sensors to rapidly measure β-lactamase enzymes in wound models. The goal is to develop sensors for use in diagnosing infection in collaboration with the UK Health Security Agency (UKHSA). The sensors developed will be miniature with ease of operation to allow point of care analysis, like blood glucose testing. 

Open to any UK or international candidates. Up to 30% of our UKRI funded studentships can be awarded to candidates paying international rate fees.

You will need to meet the minimum entry requirements for our PhD programme.