Dr Qibo Zhang BSc MD PhD

Selected peer-reviewed publications

1. Sharwani K, Sharma R, Krishnan M, Temperton NA, McNamara PS, Cunliffe NA, Turtle L, Zhang Q.  Detection of serum cross-reactive antibodies and memory response to SARS-CoV-2  in pre-pandemic and post-COVID-19 convalescent samples. J Infect Dis 2021. Doi: 10.1093/infdis/jiab333.

1. Xu R, Shears RK, Sharma R, Krishna M, Webb C, Ali R, Wei X, Kadioglu A, Zhang Q. IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue. Mucosal Immunology Jan 2020. doi:10.1038/s41385-019-0246-1.

1. Saengchoowong S, Khongnomnan K, Poomipak W, Praianantathavorn K, Poovorawan Y, Zhang Q, Payungporn S. High-Throughput MicroRNA Profiles of Permissive Madin-Darby Canine Kidney Cell Line Infected with Influenza B Viruses. Viruses 2019, 11(11), 986; https://doi.org/10.3390/v11110986.

1.  Puksuriwong S, Ahmed MS, Sharma R, Krishnan M, Leong S, Lambe T, McNamara PS, Gilbert SC, Zhang Q. MVA-NP+M1 vaccine activates mucosal M1-specific T cell immunity and tissue-resident memory T cells in human nasopharynx-associated lymphoid tissue. J Infect Dis. 2019, https://doi.org/10.1093/ infdis/ jiz593

1. Ascough S, Vlachantoni I, Kalyan M, Haijema B, Wallin-Weber S, Dijkstra-Tiekstra M, Ahmed MS, van Roosmalen M, Grimaldi R, Zhang Q, et al. Local and Systemic Immunity Against RSV Induced by a Novel Intranasal Vaccine: A Randomised, Double- Blind, Placebo-Controlled Trial. Am J Respir Crit Care Med. 2019; 15;200(4):481-492

1. Aljurayyan A, Puksuriwong S, Ahmed M, Sharma R, Krishnan M, Sood S, Davies K, Rajashekar D, Leong S, McNamara PS, Gordon S, Zhang Q. Activation and induction of antigen-specific T follicular helper cells (TFH) play a critical role in LAIV-induced human mucosal anti-influenza antibody response. J Virol. 2018 Mar 21. doi: 10.1128/JVI.00114-18.

1. Kim MY, Copland A, Nayak K, Chandele A, Ahmed MS, Zhang Q et al, Plant-expressed Fc-fusion protein tetravalent dengue vaccine with inherent adjuvant properties. Plant Biotechnol J. 2018; 16 (7). 1283 – 1294.

1. Mahallawi WH., Khabour OF, Zhang Q, Makhdoum HM, Suliman BA, MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile. Cytokine 2018 Apr;104:8-13. doi: 10.1016/j.cyto.2018.01.025.

1. Mubarak A, Ahmed MS, Upile N, Paton JC, Mitchell T, Cunliffe N, Zhang Q. A dynamic relationship between mucosal Th17 and Treg in nasopharynx evolves with age and appears a critical determinant associated with the clearance of pneumococcal carriage in humans. Clin Microbiol & Infect. 2016;10.1016/j.cmi.2016.05.017

1. Aljurayyan AN, Sharma R, Upile N, Beer H, Vaughan C, Xie C, Achar P, Ahmed MS, McNamara P, Gordon S, Zhang Q. A critical role of T follicular helper cells in human mucosal anti-influenza response that can be enhanced by immunological adjuvant CpG-DNA. Antiviral Research 2016, doi:10.1016/j.antiviral

1. Mullin J, Ahmed MS, Sharma R, Temperton N, McNamara P, Lambe T, Gilbert SC, Zhang Q. Activation of cross-reactive mucosal T and B cell responses in human nasopharynx-associated lymphoid tissue in vitro by Modified Vaccinia Ankara-vectored influenza vaccines. Vaccine 2016; 34(14): 1688-1695
2. Ahmed MS, Jacques LC, Mahallawi W, Ferrara F, Temperton N,, Upile N, Vaughan C, Sharma R, Beer H, Hoschler K, McNamara PS, Zhang Q. Cross-reactive immunity against influenza viruses in children and adults following 2009 pandemic H1N1 infection. Antiviral Research. 2015 Feb;114:106-12..
3. Ahmed MS, Derbyshire S, Flannagan B,  Loh C, McCormick M, Barocchi M, Masignani V, Finn A and Zhang Q. Natural immunity to pneumococcal pilus RrgA and RrgB antigens and its relationship with pneumococcal carriage in children and adults. Journal of Infection (2014) Jun;68(6):562-71  
4. Gray C, Ahmed MS, Mubarak A, Kasbekar A, Derbyshire S, McCormick M, McNamara P, Mitchell T, and Zhang Q. Activation of memory Th17 cells by domain 4 pneumolysin in human nasal-associated lymphoid tissue and its association with pneumococcal carriage. Mucosal Immunology 2014; 7, 705–717.
5. Mahallawi W, Kasbekar A, McCormick M, Hoschler K, Temperton N, McNamara P and  Zhang Q. 2009 H1N1 infection primes for immunological memory in human nasal-associated lymphoid tissue that offers cross-reactive immunity to H1N1 and avian H5N1 viruses. Journal of Virology. 2013, 87(10):5331.
6. Zhang Q, Leong SC, McNamara P, et al.  Characterisation of regulatory T cells in nasal associated lymphoid tissue in children: relationships with pneumococcal colonization. PLoS Pathogens  2011; 7(8): e1002175.
7. Dogan S, Zhang Q, Pridmore AC, et al. Pneumolysin-induced CXCL8 production by nasopharyngeal epithelial cells is dependent on MAPK via Toll-like receptor 4. Microbes and Infection 2011;13:65-75.
8. Zhang Q, Bagrade L, Clarke E, et al. Bacterial Lipoproteins Differentially Regulate Human Primary and Memory CD4+ T and B Cell Responses to Pneumococcal Protein Antigens through Toll-like receptor 2. J Infect Dis  2010; 201:1753-1763 
9. Wu Y, Zhang Q, Sales D, et al. Vaccination with peptide mimotopes produces antibodies recognizing bacterial capsular polysaccharides. Vaccine 2010; 28:6425-6435
10. Mureithi M, Finn A, Zhang Q, et al. T Cell Memory Response to Pneumococcal Protein Antigens in an Area of High Pneumococcal Carriage and Disease. J Infect Dis 2009;200(5):783-793.
11. Lu Y-J, Gross J, Bogaert D, Finn A, Bagrade L, Zhang Q, et al. Interleukin-17A Mediates Acquired Immunity to Pneumococcal Colonization. PLoS Pathogens  2008;4(9):e1000159.
12. Bernatoniene  J,  Zhang Q, et al.  Induction of CC & CXC chemokines in human antigen presenting cells by pneumococcal proteins, the role of TLR4, NFkB & MAPKinases. J Infect Dis 2008; 198(12):1823-1833.
13. Zhang Q, Bernatoniene J, Bagrade L, et al.. Low CD4 T cellular immunity to pneumolysin is associated with nasopharyngeal carriage in children. J Infect Dis 2007;195:1194-1202
14.  Zhang Q, Bernatoniene J, et al. Regulation of mucosal antibody production to pneumococcal protein antigens by T-cell derived IFNg and IL-10 in children. Infection and Immunity 2006;74(8): 4735-4743.
15. Zhang Q,  Bernatoniene J, et al. Serum and mucosal antibody responses to pneumococcal protein antigens in children: relationships with carriage status. Euro J Immunol 2006; 36:46-57.
16. Gordon SB. Janoff EN. Sloper D. Zhang Q. et al. HIV-1 infection is associated with altered innate pulmonary immunity. J Infect Dis 2005;192(8):1412-6
17. Zhang Q, Arnaoutakis K, et al. Mucosal responses to capsular polysaccharides in immunized pre-school children with similar nasal pneumococcal colonization rates. Pediatr Infect Dis J  2004; 23:307-13.
18. Zhang Q and Finn A Mucosal immunology of vaccines against pathogenic nasopharyngeal bacteria. J Clin Pathol  2004;57(10): 1015-21
19. Murdoch C, Read RC, Zhang Q, Finn A. CbpA of S. pneumoniae elicits chemokine production and expression of ICAM-1/CD54 by human alveolar epithelial cells. J Infect Dis 2002;186:1253-1260.
20. Finn A, Zhang Q, Seymour L, et al. Induction of functional   secretory IgA responses in breast milk by pneumococcal capsular polysaccharides. J Infect Dis 2002;186:1422-1429.
21. Zhang Q, Choo S. Finn A. Immune responses to novel pneumococcal proteins Pneumolysin, PspA, PsaA and CbpA in adenoidal B cells from children. Infection and Immunity 2002; 70: 5363-5369.
22. Zhang,Q. Pettitt,E. Burkinshaw,R. Race,G. Shaw,L. Finn,A.  Mucosal immune responses to meningococcal conjugate polysaccharide vaccines in infants. Pediatr Infect Dis J 2002;21(3):209-213.
23. Zhang Q, Finn A. Conjugate vaccines and airway colonization. Vaccines: Children & Practice, 2002; 5: 20-22
24. Zhang Q, Lakshman R, Burkinshaw R, Choo S, Everard J, Akhtar S, Finn A. Primary and booster mucosal immune responses to meningococcal A/C conjugate and meningococcal A/C polysaccharide vaccines in UK university students. Infection and Immunity 2001;69:4337-4341.
25. Choo S, Zhang Q, L Seymour, S Lockhart, Cartwright K, Finn A. Primary and booster serum and mucosal immune responses to a 7-valent Pneumococcal conjugate vaccine in UK infants J Infect Dis 2000;182:1260-1263.
26. Zhang Q, Choo S, Everard J, Jennings R, Finn A.  Mucosal immune responses to meningococcal C conjugate and A/C polysaccharide vaccines in adolescents. Infection and Immunity 2000;68:2692-2697.
27. Zhang Q, Etolhi G, Dawodu JB, Gemmell CG, Russell RI. Relationship between mucosal levels of Helicobacter pylori specific IgA, interleukin 8 and gastric inflammation. Clinical Science 1999;96:409-414.
28.  Zhang Q, Etolhi G, Dawodu JB, Gemmell CG, Russell RI. Relationship between mucosal production interleukin 8 and toxinogenicity of Helicobacter pylori.  Inflammopharmacology  1998;6:109-117.
29.  Zhang Q, Dawodu, et al. Relationship between the mucosal production of reactive oxygen radicals and density of Helicobacter pylori in patients with duodenal ulcer. Euro J Gastroenterol Heptol 1997;9:261-265.
30.  Zhang Q, Dawodu JB, Husain A, Gemmell CG, Russell RI. Association of antral mucosal production of interleukin-8 and reactive oxygen radicals in patients with Helicobacter pylori infection. Clinical Science 1997;92:69-73.
31.  Nakshabendi IM, Zhang Q, Lee FD, Gemmell CG, Russell RI. Effect of omeprazole therapy on the survival of Helicobacter pylori, urease activity and antral gastric histology in patients with duodenal ulcer. Helicobacter 1996;1(3):155-158.
32.  Zhang Q, Nakshabendi IM, Mokhashi MS, Gemmell CG, Russell RI. Association of cytotoxin production and neutrophil activation by strains of Helicobacter pylori isolated from patients with peptic ulcer and chronic gastritis. Gut 1996;38:841-845.