Prince Okyere
About
My research project
Non-invasive deep brain stimulation of the hippocampus during sleepThe hippocampus is involved in storing new memories and during sleep, it communicates with the neocortex to help consolidate these new memories. Cortical slow waves (0.5-4 Hz), thalamocortical sleep spindles (12-15 Hz) and hippocampal ripples (80-120 Hz) are hallmark features of non-rapid eye movement (NREM) sleep and they are believed to systematically interact with each other to facilitate memory consolidation. However, the mechanisms by which these sleep neural oscillations interact to facilitate memory consolidation in humans are still not well understood.
My research uses Temporal Interference electrical stimulation (TI) - a novel non-invasive brain stimulation approach whereby neural activity is modulated by the application of two kHz range electric fields with a difference frequency within the range of neural activity. I combine this technique with EEG or fMRI during sleep to provide a better understanding of hippocampal-cortical connectivity and create interventions to improve memory consolidation during sleep.
Supervisors
The hippocampus is involved in storing new memories and during sleep, it communicates with the neocortex to help consolidate these new memories. Cortical slow waves (0.5-4 Hz), thalamocortical sleep spindles (12-15 Hz) and hippocampal ripples (80-120 Hz) are hallmark features of non-rapid eye movement (NREM) sleep and they are believed to systematically interact with each other to facilitate memory consolidation. However, the mechanisms by which these sleep neural oscillations interact to facilitate memory consolidation in humans are still not well understood.
My research uses Temporal Interference electrical stimulation (TI) - a novel non-invasive brain stimulation approach whereby neural activity is modulated by the application of two kHz range electric fields with a difference frequency within the range of neural activity. I combine this technique with EEG or fMRI during sleep to provide a better understanding of hippocampal-cortical connectivity and create interventions to improve memory consolidation during sleep.