Dr Mohammad Asim
About
Biography
Dr. Mohammad Asim is a Cancer Molecular Biologist who studies molecular mechanisms that drive prostate cancer progression in order to find novel and more effective treatments. His research has primarily focussed on understanding the role of the androgen receptor signalling in prostate cancer and how it is activated in cancer leading to drug resistance. Mohammad graduated with a PhD from Justus Liebig University for his work uncovering the role of signal transduction pathways and transcriptional corepressors in regulating androgen receptor signalling in prostate cancer.
Following a postdoc in Cancer therapeutics at the University of Wisconsin, where he discovered novel anti-androgens, he took up a Senior Scientist position at the Cancer Research UK Cambridge Institute at the University of Cambridge. Here, Mohammad's ground-breaking work identified the first-ever mammalian kinase that can act as a chaperone for the androgen receptor and is a drug target. At Surrey, his work uncovered a novel synthetic lethal relationship between the androgen receptor and Poly (ADP-Ribose) Polymerase pathway which is being clinically exploited to treat castration-resistant prostate cancer (CRPC). His lab identified PDZ binding Kinase as a mediator of androgen receptor function in CRPC thus revealing the molecular mechanism underlying the failure of hormone therapy for prostate cancer. This work contributed to understanding pathways that can cause the failure of hormone/radiation therapy and can thus be exploited in developing combination approaches for effective cancer treatment. For his discoveries on a novel dual-activity anti-androgenic drug currently in development, Dr Asim was awarded a Young Investigator Award from the Prostate Cancer Foundation. In addition to his role at Surrey, Dr Asim concurrently holds a visiting scientist post at the University of Cambridge.
Areas of specialism
University roles and responsibilities
- Academic Integrity Officer
- Visiting Tutor Professional Training Year
- Personal Tutor
- MD/PhD examiner
- Module Organiser
- Research Supervisor
My qualifications
PhD thesis studying the role of signal transduction and transcriptional cofactors in the regulation of androgen receptor function in prostate cancer
Affiliations and memberships
2. American Association for Cancer Research
3. Higher Education Academy of the United Kingdom
4. The Royal Society of Biology of the United Kingdom
News
In the media
ResearchResearch interests
Biography
Dr. Mohammad Asim graduated with a first-class Bachelor's in Science, and a Master's in Science degree from Hamdard University, New Delhi, India. The Justus Liebig University in Germany awarded him a PhD degree for his work uncovering the role of signal transduction pathways and transcriptional corepressors in the regulation of Androgen Receptor (AR) signalling in prostate cancer (PCa). His PhD work identified LCoR as a novel transcriptional corepressor for the AR and uncovered its cross-talk with the Src kinase pathway. During his postdoctoral training post in Cancer Cell Biology at the University of Wisconsin, Madison, USA where he identified novel small molecules with the potential to inhibit AR signalling in PCa. Later he took up a senior scientist position at the CR UK Institute of the University of Cambridge, UK. While at Cambridge he led the androgen signalling research theme of the Uro oncology lab and trained several scientists. After spending more than 6 years at Cambridge, he joined the University of Surrey in December 2016 as an acaddemic.
Mohammad has over a decade of experience researching the molecular mechanisms that lead to prostate cancer progression. His research has focussed on understanding the role of AR in PCa and has been proven vital in finding novel treatments for aggressive PCa.
Research interests
Lethal prostate cancer: Understanding Molecular Mechanisms to identify effective treatments
Mohammad has a keen interest and research expertise in the area of Prostate cancer (PCa). PCa is a leading cause of cancer-related mortality in the United Kingdom with 11,000 deaths each year. Advanced PCa is often treated with hormone therapy and radiation. While a number of patients are treated and become disease-free, recurrent PCa is standard and leads to the development of castration-resistant PCa (CRPC) which is metastatic. Mohammad's research focus is on why hormone/radiation therapy fails and how cancer becomes aggressive.
Dr Asim strongly believes that multi-dimension interdisciplinary research to attack PCa from different angles holds the key to the development of successful therapies with sustained clinical benefits. In terms of understanding the underlying biology behind the aggressive disease that allows the disease to progress and become aggressive is vital in identifying novel therapeutic targets and thus important in designing novel therapies to treat PCa. Mohammad's current research projects include:
1. Understanding the onset of aggressive PCa to develop precision diagnostic tools.
2. To understand the function of androgen receptor and associated pathways in CRPC.
3. Identification and validation of novel potential drug targets in PCa.
4. Designing novel therapeutic strategies to block PCa progression.
Dr Asim is pleased to consider applications from prospective doctoral students and self-funded postdocs.
Honorary Affiliations
1. Visiting Scientist, Cancer Research UK Cambridge Institute, University of Cambridge, UK.
2. Member of the Surrey Cancer Research Institute, University of Surrey-Royal Surrey County Hospital, UK.
Patent & clinical trial
Lead contributor in the discovery for which, a United States patent (#US20100010078 A1) has been obtained “Method of treating androgen-dependent prostate cancer by administering an active pharmaceutical ingredient being Fisetin, 3,3',4',7- tertahydroxyflavone or a derivative thereof, in an oral, transdermal or topical dosage form.”
Member of the clinical trial management committee of the clinical trial entitled “A study into the pharmacodynamic biomarker effects of Olaparib (a PARP inhibitor) given prior to radical prostatectomy” protocol number CANCAP03, at the University of Cambridge Addenbrooke's Hospital, Cambridge. The study was funded by AZ.
Editorial Roles
1. Senior Scientific Editor for Elsevier’s Neoplasia and Translational Oncology journals.
2. Review Editor for Frontiers in Oncology, Member of the editorial board of Translational Oncology, Cells & Receptors
3. Guest Editor for the Special Issue on Understanding and Targeting Androgen Receptor Signalling in Prostate Cancer (Cells; published in December 2021).
Ad hoc reviewer invitations
Nature Genetics, Nature Communications, The Journal of Clinical Investigation, Cancer Research, Clinical Cancer Research, EMBO Molecular Medicine, Oncogene, OncoTargets and Therapy, Clinical and Translational Medicine, International Journal of Cancer, Future Oncology, Epigenomics, Helicobacter, Molecular Cancer Research, Frontiers in Oncology, Oncogenesis, Cancer Letters, Cell Death and Disease, Molecular and Cellular Biochemistry, BMC Urology, The Journal of Biochemical and Molecular Toxicology, PLoS One, Hormones and Cancer, Endocrine-related Cancer, Pharmaceutical Biology, Diagnostic Pathology, Tumour Biology, Life Sciences, International Journal of Molecular Sciences, Journal of Proteome Research, Neuroscience, Drug Development Research, Environmental Science and Pollution Research, Toxicology Mechanisms and Methods, Open Biology, Journal of Clinical Medicine, Asian Journal of Andrology, Archives of Biochemistry and Biophysics, Cellular Physiology and Biochemistry, European Journal of Pharmacology, Translational Oncology, Cells, Molecular Biology Reports, Scientific Reports, Cancer Biomarkers, Cells, Molecular Systems Biology, EMBO Reports.
Research interests
Biography
Dr. Mohammad Asim graduated with a first-class Bachelor's in Science, and a Master's in Science degree from Hamdard University, New Delhi, India. The Justus Liebig University in Germany awarded him a PhD degree for his work uncovering the role of signal transduction pathways and transcriptional corepressors in the regulation of Androgen Receptor (AR) signalling in prostate cancer (PCa). His PhD work identified LCoR as a novel transcriptional corepressor for the AR and uncovered its cross-talk with the Src kinase pathway. During his postdoctoral training post in Cancer Cell Biology at the University of Wisconsin, Madison, USA where he identified novel small molecules with the potential to inhibit AR signalling in PCa. Later he took up a senior scientist position at the CR UK Institute of the University of Cambridge, UK. While at Cambridge he led the androgen signalling research theme of the Uro oncology lab and trained several scientists. After spending more than 6 years at Cambridge, he joined the University of Surrey in December 2016 as an acaddemic.
Mohammad has over a decade of experience researching the molecular mechanisms that lead to prostate cancer progression. His research has focussed on understanding the role of AR in PCa and has been proven vital in finding novel treatments for aggressive PCa.
Research interests
Lethal prostate cancer: Understanding Molecular Mechanisms to identify effective treatments
Mohammad has a keen interest and research expertise in the area of Prostate cancer (PCa). PCa is a leading cause of cancer-related mortality in the United Kingdom with 11,000 deaths each year. Advanced PCa is often treated with hormone therapy and radiation. While a number of patients are treated and become disease-free, recurrent PCa is standard and leads to the development of castration-resistant PCa (CRPC) which is metastatic. Mohammad's research focus is on why hormone/radiation therapy fails and how cancer becomes aggressive.
Dr Asim strongly believes that multi-dimension interdisciplinary research to attack PCa from different angles holds the key to the development of successful therapies with sustained clinical benefits. In terms of understanding the underlying biology behind the aggressive disease that allows the disease to progress and become aggressive is vital in identifying novel therapeutic targets and thus important in designing novel therapies to treat PCa. Mohammad's current research projects include:
1. Understanding the onset of aggressive PCa to develop precision diagnostic tools.
2. To understand the function of androgen receptor and associated pathways in CRPC.
3. Identification and validation of novel potential drug targets in PCa.
4. Designing novel therapeutic strategies to block PCa progression.
Dr Asim is pleased to consider applications from prospective doctoral students and self-funded postdocs.
Honorary Affiliations
1. Visiting Scientist, Cancer Research UK Cambridge Institute, University of Cambridge, UK.
2. Member of the Surrey Cancer Research Institute, University of Surrey-Royal Surrey County Hospital, UK.
Patent & clinical trial
Lead contributor in the discovery for which, a United States patent (#US20100010078 A1) has been obtained “Method of treating androgen-dependent prostate cancer by administering an active pharmaceutical ingredient being Fisetin, 3,3',4',7- tertahydroxyflavone or a derivative thereof, in an oral, transdermal or topical dosage form.”
Member of the clinical trial management committee of the clinical trial entitled “A study into the pharmacodynamic biomarker effects of Olaparib (a PARP inhibitor) given prior to radical prostatectomy” protocol number CANCAP03, at the University of Cambridge Addenbrooke's Hospital, Cambridge. The study was funded by AZ.
Editorial Roles
1. Senior Scientific Editor for Elsevier’s Neoplasia and Translational Oncology journals.
2. Review Editor for Frontiers in Oncology, Member of the editorial board of Translational Oncology, Cells & Receptors
3. Guest Editor for the Special Issue on Understanding and Targeting Androgen Receptor Signalling in Prostate Cancer (Cells; published in December 2021).
Ad hoc reviewer invitations
Nature Genetics, Nature Communications, The Journal of Clinical Investigation, Cancer Research, Clinical Cancer Research, EMBO Molecular Medicine, Oncogene, OncoTargets and Therapy, Clinical and Translational Medicine, International Journal of Cancer, Future Oncology, Epigenomics, Helicobacter, Molecular Cancer Research, Frontiers in Oncology, Oncogenesis, Cancer Letters, Cell Death and Disease, Molecular and Cellular Biochemistry, BMC Urology, The Journal of Biochemical and Molecular Toxicology, PLoS One, Hormones and Cancer, Endocrine-related Cancer, Pharmaceutical Biology, Diagnostic Pathology, Tumour Biology, Life Sciences, International Journal of Molecular Sciences, Journal of Proteome Research, Neuroscience, Drug Development Research, Environmental Science and Pollution Research, Toxicology Mechanisms and Methods, Open Biology, Journal of Clinical Medicine, Asian Journal of Andrology, Archives of Biochemistry and Biophysics, Cellular Physiology and Biochemistry, European Journal of Pharmacology, Translational Oncology, Cells, Molecular Biology Reports, Scientific Reports, Cancer Biomarkers, Cells, Molecular Systems Biology, EMBO Reports.
Teaching
Undergraduate Teaching
Module leader for BSc module "Molecular Biology and Genetics: From Genes to Biological Function" (BMS2036).
Module tutor for BSc module "Molecular Biology and Genetics: From Genes to Biological Function" (BMS1047).
Module tutor for BSc module "Advanced Technologies in Gene Expression" (BMS3092).
Dissertation supervisor for the BSc Research Project (BMS3048).
Postgraduate Teaching
Module leader for MSci Biomedical Science module "Cellular and Molecular Pathology" (BMSM028).
Publications
In the last decade, treatment for castration-resistant prostate cancer has changed markedly, impacting symptom control and longevity for patients. However, a large proportion of cases progress despite androgen deprivation therapy and chemotherapy, while still being fit enough for several more lines of treatment. Overstimulation of the androgen receptor (AR) activity is the main driver of this cancer. Targeting biological functions of the AR or its co-regulators has proven very effective in this disease and led to the development of several highly effective drugs targeting the AR signalling axis. Drugs such as enzalutamide demonstrated that the improvement in anti-tumour efficacy is closely correlated with an affinity for the AR and its activity and have established the paradigm that AR remains activity in aggressive disease. However, as importantly, key insights into mechanisms of resistance are guiding the development of the next generation of AR-targeted drugs. This review outlines the historical development of these highly specific agents, their mechanism of action in the context of defective AR activity, and explores the potential for the upcoming next-generation AR inhibitors (ARI) for prostate cancer by targeting the alternative domains of AR, rather than by the conventional ligand-binding domain approach. There is huge potential in these approaches to develop new drugs with high clinical activity and further improve the outlook for patients.