Dr Kourosh R Ahmadi
About
Biography
I am one of the leading national and international advocates and researchers of the “Precision” Public Health (PPH) principle.
Career contributions
I have made 4 important research-related contributions so far in my career. First, is to use genomic mapping tools to study inter-individual response to both medications (pharmacogenomics) and nutrients (nutrigenomics). These include pharmacogenomics studies of hypersensitivity to beta-lactam antibiotics and aspirin sensitive asthma as well as genomic and metabolomics studies of response to B-vitamins. The second has been to advocate the use of the classical twin model in pharmaco/nutrigenomic as well as other “Omics” studies for biomarker validation/discovery (See for example the Wellcome trust funded MuTHER study: www.muther.ac.uk/). We were amongst the first groups to report heritability estimates of B-vitamin biomarker status among the general population, were the first to use twin studies to show that the genetic architecture of nutrient status is different to the architecture of response (e.g. to supplement use) and leading efforts to identify genes associated with population variability for a myriad of micronutrients (vitamins B, D, and minerals calcium, Selenium, iodine) within important contexts (pregnancy, old age) and to use Mendelian randomisation studies to prove or disprove causal links between micronutrient levels and diseases (cardiovascular and ischaemic stroke). My third contribution has been on method development and critical analysis of “Omics” platforms. As part of the group at the Galton labs (UCL) we were one of the first groups to try and leverage linkage disequilibrium for mapping the human genome and devised the haplotype “tagging” approach and within the MolPAGE study (cordis.europa.eu/project/id/512066) I led the work package using the classical twin design to show the scope of molecular phenotyping in accelerating genomic epidemiology studies but the degree of technical variability outweighs the biological information for many of the platforms. Finally, my final contribution is to marry the field of human genetics, nutritional and social sciences. As part of my risk management work portfolio the translation of the most basic of research – in particular nutrition & genetics – requires involvement of the social sciences and so currently under the “food citizenship” remit I am actively gauging the utility of genetic risk in devising and refining the messaging and practice of nutrition risk management.
Areas of specialism
Teaching
I currently teach on the following modules within the Nutrition and Nutrition and Dietetics BSc degrees:
- Advances in Nutrition: Health & Disease (BMS3067):
- B-vitamins: focus on vitamins B2, B6, B9, B12
- One-carbon metabolism: homocysteine in health & disease
- Fundamentals of Human Nutrition (MNH01):
- B-vitamins - A Primer
- Folate: Homocysteine Metabolism
- Molecular Nutrition (MHN06):
- Fundamentals of Human Genetics
- Vitamins and Gene Expression
- Nutrition and Ageing (NutMed: Module 7):
- Nutritional influences on dementia and AD
- Principles of Applied Nutrition and Epidemiology (NutMed: Module 2):
- Introduction
- Nutrition Research Methodology (MHN05)
I also organise two modules:
- Human Nutrition MSc: Module 5 (MHU05) Nutrition Research Methodology
- Nutritional Medicine MSc: Module 2 - Principles of Applied Nutrition and Epidemiology
Publications
Highlights
Vitamin B12 status in health and disease: a critical review. Diagnosis of deficiency and insufficiency - clinical and laboratory pitfalls. Sobczyńska-Malefora A, Delvin E, McCaddon A, Ahmadi KR, Harrington DJ.Crit Rev Clin Lab Sci. 2021 Apr 21:1-31.
A critical evaluation of results from genome-wide association studies of micronutrient status and their utility in the practice of precision nutrition. Dib MJ, Elliott R, Ahmadi KR.Br J Nutr. 2019 Jul 28;122(2):121-130.
A genetic epidemiological study in British adults and older adults shows a high heritability of the combined indicator of vitamin B12 status (cB12) and connects B12 status with utilization of mitochondrial substrates and energy metabolism. Dalmia A, Dib MJ, Maude H, Harrington DJ, Sobczyńska-Malefora A, Andrew T, Ahmadi KR.J Nutr Biochem. 2019 Aug;70:156-163.
Interaction between plasma homocysteine and the MTHFR c.677C > T polymorphism is associated with site-specific changes in DNA methylation in humans. Nash AJ, Mandaviya PR, Dib MJ, Uitterlinden AG, van Meurs J, Heil SG, Andrew T, Ahmadi KR.FASEB J. 2019 Jan;33(1):833-843.
1: Sobczyńska-Malefora A, Delvin E, McCaddon A, Ahmadi KR, Harrington DJ.
Vitamin B<sub>12</sub> status in health and disease: a critical review.
Diagnosis of deficiency and insufficiency - clinical and laboratory pitfalls.
Crit Rev Clin Lab Sci. 2021 Apr 21:1-31. doi: 10.1080/10408363.2021.1885339.
Epub ahead of print. PMID: 33881359.
2: Darling AL, Blackbourn DJ, Ahmadi KR, Lanham-New SA. Very high prevalence of
25-hydroxyvitamin D deficiency in 6433 UK South Asian adults: analysis of the UK
Biobank Cohort. Br J Nutr. 2021 Feb 28;125(4):448-459. doi:
10.1017/S0007114520002779. Epub 2020 Jul 22. PMID: 32693845; PMCID: PMC7844605.
3: Dib MJ, Elliott R, Ahmadi KR. A critical evaluation of results from genome-
wide association studies of micronutrient status and their utility in the
practice of precision nutrition. Br J Nutr. 2019 Jul 28;122(2):121-130. doi:
10.1017/S0007114519001119. Epub 2019 Jul 31. PMID: 31362796.
4: Dalmia A, Dib MJ, Maude H, Harrington DJ, Sobczyńska-Malefora A, Andrew T,
Ahmadi KR. A genetic epidemiological study in British adults and older adults
shows a high heritability of the combined indicator of vitamin B<sub>12</sub>
status (cB<sub>12</sub>) and connects B<sub>12</sub> status with utilization of
mitochondrial substrates and energy metabolism. J Nutr Biochem. 2019
Aug;70:156-163. doi: 10.1016/j.jnutbio.2019.04.008. Epub 2019 May 14. PMID:
31203192.
5: Nash AJ, Mandaviya PR, Dib MJ, Uitterlinden AG, van Meurs J, Heil SG, Andrew
T, Ahmadi KR. Interaction between plasma homocysteine and the MTHFR c.677C > T
polymorphism is associated with site-specific changes in DNA methylation in
humans. FASEB J. 2019 Jan;33(1):833-843. doi: 10.1096/fj.201800400R. Epub 2018
Aug 6. PMID: 30080444.
6: Darling AL, Blackbourn DJ, Ahmadi KR, Lanham-New SA. Vitamin D supplement use
and associated demographic, dietary and lifestyle factors in 8024 South Asians
aged 40-69 years: analysis of the UK Biobank cohort. Public Health Nutr. 2018
Oct;21(14):2678-2688. doi: 10.1017/S1368980018001404. Epub 2018 Jun 25. PMID:
29936916.
7: Mao J, Vanderlelie JJ, Perkins AV, Redman CW, Ahmadi KR, Rayman MP. Genetic
polymorphisms that affect selenium status and response to selenium
supplementation in United Kingdom pregnant women. Am J Clin Nutr. 2016
Jan;103(1):100-6. doi: 10.3945/ajcn.115.114231. Epub 2015 Dec 16. PMID:
26675765; PMCID: PMC4691667.
8: Allum F, Shao X, Guénard F, Simon MM, Busche S, Caron M, Lambourne J, Lessard
J, Tandre K, Hedman ÅK, Kwan T, Ge B; Multiple Tissue Human Expression Resource
Consortium, Rönnblom L, McCarthy MI, Deloukas P, Richmond T, Burgess D, Spector
TD, Tchernof A, Marceau S, Lathrop M, Vohl MC, Pastinen T, Grundberg E. Erratum:
Characterization of functional methylomes by next-generation capture sequencing
identifies novel disease-associated variants. Nat Commun. 2015 Jul 29;6:8016.
doi: 10.1038/ncomms9016. Erratum for: Nat Commun. 2015;6:7211. PMID: 26219997;
PMCID: PMC7188456.
9: Allum F, Shao X, Guénard F, Simon MM, Busche S, Caron M, Lambourne J, Lessard
J, Tandre K, Hedman ÅK, Kwan T, Ge B; Multiple Tissue Human Expression Resource
Consortium, Rönnblom L, McCarthy MI, Deloukas P, Richmond T, Burgess D, Spector
TD, Tchernof A, Marceau S, Lathrop M, Vohl MC, Pastinen T, Grundberg E.
Characterization of functional methylomes by next-generation capture sequencing
identifies novel disease-associated variants. Nat Commun. 2015 May 29;6:7211.
doi: 10.1038/ncomms8211. Erratum in: Nat Commun. 2015;6:8016. PMID: 26021296;
PMCID: PMC4544751.
10: Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C,
Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T, Fall T, Ferreira
T, Gustafsson S, Kutalik Z, Luan J, Mägi R, Randall JC, Winkler TW, Wood AR,
Workalemahu T, Faul JD, Smith JA, Zhao JH, Zhao W, Chen J, Fehrmann R, Hedman
ÅK, Karjalainen J, Schmidt EM, Absher D, Amin N, Anderson D, Beekman M, Bolton
JL, Bragg-Gresham JL, Buyske S, Demirkan A, Deng G, Ehret GB, Feenstra B,
Feitosa MF, Fischer K, Goel A, Gong J, Jackson AU, Kanoni S, Kleber ME,
Kristiansson K, Lim U, Lotay V, Mangino M, Leach IM, Medina-Gomez C, Medland SE,
Nalls MA, Palmer CD, Pasko D, Pechlivanis S, Peters MJ, Prokopenko I, Shungin D,
Stančáková A, Strawbridge RJ, Sung YJ, Tanaka T, Teumer A, Trompet S, van der
Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W,
Isaacs A, Albrecht E, Ärnlöv J, Arscott GM, Attwood AP, Bandinelli S, Barrett A,
Bas IN, Bellis C, Bennett AJ, Berne C, Blagieva R, Blüher M, Böhringer S,
Bonnycastle LL, Böttcher Y, Boyd HA, Bruinenberg M, Caspersen IH, Chen YI,
Clarke R, Daw EW, de Craen AJM, Delgado G, Dimitriou M, Doney ASF, Eklund N,
Estrada K, Eury E, Folkersen L, Fraser RM, Garcia ME, Geller F, Giedraitis V,
Gigante B, Go AS, Golay A, Goodall AH, Gordon SD, Gorski M, Grabe HJ, Grallert
H, Grammer TB, Gräßler J, Grönberg H, Groves CJ, Gusto G, Haessler J, Hall P,
Haller T, Hallmans G, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer
Q, Hengstenberg C, Holmen O, Hottenga JJ, James AL, Jeff JM, Johansson Å, Jolley
J, Juliusdottir T, Kinnunen L, Koenig W, Koskenvuo M, Kratzer W, Laitinen J,
Lamina C, Leander K, Lee NR, Lichtner P, Lind L, Lindström J, Lo KS, Lobbens S,
Lorbeer R, Lu Y, Mach F, Magnusson PKE, Mahajan A, McArdle WL, McLachlan S,
Menni C, Merger S, Mihailov E, Milani L, Moayyeri A, Monda KL, Morken MA, Mulas
A, Müller G, Müller-Nurasyid M, Musk AW, Nagaraja R, Nöthen MM, Nolte IM, Pilz
S, Rayner NW, Renstrom F, Rettig R, Ried JS, Ripke S, Robertson NR, Rose LM,
Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Scott WR, Seufferlein T, Shi
J, Smith AV, Smolonska J, Stanton AV, Steinthorsdottir V, Stirrups K, Stringham
HM, Sundström J, Swertz MA, Swift AJ, Syvänen AC, Tan ST, Tayo BO, Thorand B,
Thorleifsson G, Tyrer JP, Uh HW, Vandenput L, Verhulst FC, Vermeulen SH, Verweij
N, Vonk JM, Waite LL, Warren HR, Waterworth D, Weedon MN, Wilkens LR, Willenborg
C, Wilsgaard T, Wojczynski MK, Wong A, Wright AF, Zhang Q; LifeLines Cohort
Study, Brennan EP, Choi M, Dastani Z, Drong AW, Eriksson P, Franco-Cereceda A,
Gådin JR, Gharavi AG, Goddard ME, Handsaker RE, Huang J, Karpe F, Kathiresan S,
Keildson S, Kiryluk K, Kubo M, Lee JY, Liang L, Lifton RP, Ma B, McCarroll SA,
McKnight AJ, Min JL, Moffatt MF, Montgomery GW, Murabito JM, Nicholson G, Nyholt
DR, Okada Y, Perry JRB, Dorajoo R, Reinmaa E, Salem RM, Sandholm N, Scott RA,
Stolk L, Takahashi A, Tanaka T, van 't Hooft FM, Vinkhuyzen AAE, Westra HJ,
Zheng W, Zondervan KT; ADIPOGen Consortium; AGEN-BMI Working Group;
CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC
Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen
Consortium; GENIE Consortium; International Endogene Consortium, Heath AC,
Arveiler D, Bakker SJL, Beilby J, Bergman RN, Blangero J, Bovet P, Campbell H,
Caulfield MJ, Cesana G, Chakravarti A, Chasman DI, Chines PS, Collins FS,
Crawford DC, Cupples LA, Cusi D, Danesh J, de Faire U, den Ruijter HM,
Dominiczak AF, Erbel R, Erdmann J, Eriksson JG, Farrall M, Felix SB, Ferrannini
E, Ferrières J, Ford I, Forouhi NG, Forrester T, Franco OH, Gansevoort RT,
Gejman PV, Gieger C, Gottesman O, Gudnason V, Gyllensten U, Hall AS, Harris TB,
Hattersley AT, Hicks AA, Hindorff LA, Hingorani AD, Hofman A, Homuth G, Hovingh
GK, Humphries SE, Hunt SC, Hyppönen E, Illig T, Jacobs KB, Jarvelin MR, Jöckel
KH, Johansen B, Jousilahti P, Jukema JW, Jula AM, Kaprio J, Kastelein JJP,
Keinanen-Kiukaanniemi SM, Kiemeney LA, Knekt P, Kooner JS, Kooperberg C, Kovacs
P, Kraja AT, Kumari M, Kuusisto J, Lakka TA, Langenberg C, Marchand LL,
Lehtimäki T, Lyssenko V, Männistö S, Marette A, Matise TC, McKenzie CA, McKnight
B, Moll FL, Morris AD, Morris AP, Murray JC, Nelis M, Ohlsson C, Oldehinkel AJ,
Ong KK, Madden PAF, Pasterkamp G, Peden JF, Peters A, Postma DS, Pramstaller PP,
Price JF, Qi L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ridker PM, Rioux JD,
Ritchie MD, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schunkert
H, Schwarz PEH, Sever P, Shuldiner AR, Sinisalo J, Stolk RP, Strauch K, Tönjes
A, Trégouët DA, Tremblay A, Tremoli E, Virtamo J, Vohl MC, Völker U, Waeber G,
Willemsen G, Witteman JC, Zillikens MC, Adair LS, Amouyel P, Asselbergs FW,
Assimes TL, Bochud M, Boehm BO, Boerwinkle E, Bornstein SR, Bottinger EP,
Bouchard C, Cauchi S, Chambers JC, Chanock SJ, Cooper RS, de Bakker PIW,
Dedoussis G, Ferrucci L, Franks PW, Froguel P, Groop LC, Haiman CA, Hamsten A,
Hui J, Hunter DJ, Hveem K, Kaplan RC, Kivimaki M, Kuh D, Laakso M, Liu Y, Martin
NG, März W, Melbye M, Metspalu A, Moebus S, Munroe PB, Njølstad I, Oostra BA,
Palmer CNA, Pedersen NL, Perola M, Pérusse L, Peters U, Power C, Quertermous T,
Rauramaa R, Rivadeneira F, Saaristo TE, Saleheen D, Sattar N, Schadt EE,
Schlessinger D, Slagboom PE, Snieder H, Spector TD, Thorsteinsdottir U, Stumvoll
M, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Walker M,
Wallaschofski H, Wareham NJ, Watkins H, Weir DR, Wichmann HE, Wilson JF, Zanen
P, Borecki IB, Deloukas P, Fox CS, Heid IM, O'Connell JR, Strachan DP,
Stefansson K, van Duijn CM, Abecasis GR, Franke L, Frayling TM, McCarthy MI,
Visscher PM, Scherag A, Willer CJ, Boehnke M, Mohlke KL, Lindgren CM, Beckmann
JS, Barroso I, North KE, Ingelsson E, Hirschhorn JN, Loos RJF, Speliotes EK.
Genetic studies of body mass index yield new insights for obesity biology.
Nature. 2015 Feb 12;518(7538):197-206. doi: 10.1038/nature14177. PMID: 25673413;
PMCID: PMC4382211.
11: Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R,
Strawbridge RJ, Pers TH, Fischer K, Justice AE, Workalemahu T, Wu JMW,
Buchkovich ML, Heard-Costa NL, Roman TS, Drong AW, Song C, Gustafsson S, Day FR,
Esko T, Fall T, Kutalik Z, Luan J, Randall JC, Scherag A, Vedantam S, Wood AR,
Chen J, Fehrmann R, Karjalainen J, Kahali B, Liu CT, Schmidt EM, Absher D, Amin
N, Anderson D, Beekman M, Bragg-Gresham JL, Buyske S, Demirkan A, Ehret GB,
Feitosa MF, Goel A, Jackson AU, Johnson T, Kleber ME, Kristiansson K, Mangino M,
Leach IM, Medina-Gomez C, Palmer CD, Pasko D, Pechlivanis S, Peters MJ,
Prokopenko I, Stančáková A, Sung YJ, Tanaka T, Teumer A, Van Vliet-Ostaptchouk
JV, Yengo L, Zhang W, Albrecht E, Ärnlöv J, Arscott GM, Bandinelli S, Barrett A,
Bellis C, Bennett AJ, Berne C, Blüher M, Böhringer S, Bonnet F, Böttcher Y,
Bruinenberg M, Carba DB, Caspersen IH, Clarke R, Daw EW, Deelen J, Deelman E,
Delgado G, Doney AS, Eklund N, Erdos MR, Estrada K, Eury E, Friedrich N, Garcia
ME, Giedraitis V, Gigante B, Go AS, Golay A, Grallert H, Grammer TB, Gräßler J,
Grewal J, Groves CJ, Haller T, Hallmans G, Hartman CA, Hassinen M, Hayward C,
Heikkilä K, Herzig KH, Helmer Q, Hillege HL, Holmen O, Hunt SC, Isaacs A,
Ittermann T, James AL, Johansson I, Juliusdottir T, Kalafati IP, Kinnunen L,
Koenig W, Kooner IK, Kratzer W, Lamina C, Leander K, Lee NR, Lichtner P, Lind L,
Lindström J, Lobbens S, Lorentzon M, Mach F, Magnusson PK, Mahajan A, McArdle
WL, Menni C, Merger S, Mihailov E, Milani L, Mills R, Moayyeri A, Monda KL,
Mooijaart SP, Mühleisen TW, Mulas A, Müller G, Müller-Nurasyid M, Nagaraja R,
Nalls MA, Narisu N, Glorioso N, Nolte IM, Olden M, Rayner NW, Renstrom F, Ried
JS, Robertson NR, Rose LM, Sanna S, Scharnagl H, Scholtens S, Sennblad B,
Seufferlein T, Sitlani CM, Smith AV, Stirrups K, Stringham HM, Sundström J,
Swertz MA, Swift AJ, Syvänen AC, Tayo BO, Thorand B, Thorleifsson G, Tomaschitz
A, Troffa C, van Oort FV, Verweij N, Vonk JM, Waite LL, Wennauer R, Wilsgaard T,
Wojczynski MK, Wong A, Zhang Q, Zhao JH, Brennan EP, Choi M, Eriksson P,
Folkersen L, Franco-Cereceda A, Gharavi AG, Hedman ÅK, Hivert MF, Huang J,
Kanoni S, Karpe F, Keildson S, Kiryluk K, Liang L, Lifton RP, Ma B, McKnight AJ,
McPherson R, Metspalu A, Min JL, Moffatt MF, Montgomery GW, Murabito JM,
Nicholson G, Nyholt DR, Olsson C, Perry JR, Reinmaa E, Salem RM, Sandholm N,
Schadt EE, Scott RA, Stolk L, Vallejo EE, Westra HJ, Zondervan KT; ADIPOGen
Consortium; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GEFOS Consortium;
GENIE Consortium; GLGC; ICBP; International Endogene Consortium; LifeLines
Cohort Study; MAGIC Investigators; MuTHER Consortium; PAGE Consortium; ReproGen
Consortium, Amouyel P, Arveiler D, Bakker SJ, Beilby J, Bergman RN, Blangero J,
Brown MJ, Burnier M, Campbell H, Chakravarti A, Chines PS, Claudi-Boehm S,
Collins FS, Crawford DC, Danesh J, de Faire U, de Geus EJ, Dörr M, Erbel R,
Eriksson JG, Farrall M, Ferrannini E, Ferrières J, Forouhi NG, Forrester T,
Franco OH, Gansevoort RT, Gieger C, Gudnason V, Haiman CA, Harris TB, Hattersley
AT, Heliövaara M, Hicks AA, Hingorani AD, Hoffmann W, Hofman A, Homuth G,
Humphries SE, Hyppönen E, Illig T, Jarvelin MR, Johansen B, Jousilahti P, Jula
AM, Kaprio J, Kee F, Keinanen-Kiukaanniemi SM, Kooner JS, Kooperberg C, Kovacs
P, Kraja AT, Kumari M, Kuulasmaa K, Kuusisto J, Lakka TA, Langenberg C, Le
Marchand L, Lehtimäki T, Lyssenko V, Männistö S, Marette A, Matise TC, McKenzie
CA, McKnight B, Musk AW, Möhlenkamp S, Morris AD, Nelis M, Ohlsson C, Oldehinkel
AJ, Ong KK, Palmer LJ, Penninx BW, Peters A, Pramstaller PP, Raitakari OT,
Rankinen T, Rao DC, Rice TK, Ridker PM, Ritchie MD, Rudan I, Salomaa V, Samani
NJ, Saramies J, Sarzynski MA, Schwarz PE, Shuldiner AR, Staessen JA,
Steinthorsdottir V, Stolk RP, Strauch K, Tönjes A, Tremblay A, Tremoli E, Vohl
MC, Völker U, Vollenweider P, Wilson JF, Witteman JC, Adair LS, Bochud M, Boehm
BO, Bornstein SR, Bouchard C, Cauchi S, Caulfield MJ, Chambers JC, Chasman DI,
Cooper RS, Dedoussis G, Ferrucci L, Froguel P, Grabe HJ, Hamsten A, Hui J, Hveem
K, Jöckel KH, Kivimaki M, Kuh D, Laakso M, Liu Y, März W, Munroe PB, Njølstad I,
Oostra BA, Palmer CN, Pedersen NL, Perola M, Pérusse L, Peters U, Power C,
Quertermous T, Rauramaa R, Rivadeneira F, Saaristo TE, Saleheen D, Sinisalo J,
Slagboom PE, Snieder H, Spector TD, Stefansson K, Stumvoll M, Tuomilehto J,
Uitterlinden AG, Uusitupa M, van der Harst P, Veronesi G, Walker M, Wareham NJ,
Watkins H, Wichmann HE, Abecasis GR, Assimes TL, Berndt SI, Boehnke M, Borecki
IB, Deloukas P, Franke L, Frayling TM, Groop LC, Hunter DJ, Kaplan RC, O'Connell
JR, Qi L, Schlessinger D, Strachan DP, Thorsteinsdottir U, van Duijn CM, Willer
CJ, Visscher PM, Yang J, Hirschhorn JN, Zillikens MC, McCarthy MI, Speliotes EK,
North KE, Fox CS, Barroso I, Franks PW, Ingelsson E, Heid IM, Loos RJ, Cupples
LA, Morris AP, Lindgren CM, Mohlke KL. New genetic loci link adipose and insulin
biology to body fat distribution. Nature. 2015 Feb 12;518(7538):187-196. doi:
10.1038/nature14132. PMID: 25673412; PMCID: PMC4338562.
12: Cotlarciuc I, Malik R, Holliday EG, Ahmadi KR, Paré G, Psaty BM, Fornage M,
Hasan N, Rinne PE, Ikram MA, Markus HS, Rosand J, Mitchell BD, Kittner SJ,
Meschia JF, van Meurs JB, Uitterlinden AG, Worrall BB, Dichgans M, Sharma P;
METASTROKE and the International Stroke Genetics Consortium. Effect of genetic
variants associated with plasma homocysteine levels on stroke risk. Stroke. 2014
Jul;45(7):1920-4. doi: 10.1161/STROKEAHA.114.005208. Epub 2014 May 20. PMID:
24846872; PMCID: PMC4083192.
13: Ahmadi KR, Andrew T. Opportunism: a panacea for implementation of whole-
genome sequencing studies in nutrigenomics research? Genes Nutr. 2014
Mar;9(2):387. doi: 10.1007/s12263-014-0387-5. Epub 2014 Feb 18. PMID: 24535715;
PMCID: PMC3968294.
14: Bell JT, Loomis AK, Butcher LM, Gao F, Zhang B, Hyde CL, Sun J, Wu H, Ward
K, Harris J, Scollen S, Davies MN, Schalkwyk LC, Mill J; MuTHER Consortium,
Williams FM, Li N, Deloukas P, Beck S, McMahon SB, Wang J, John SL, Spector TD.
Differential methylation of the TRPA1 promoter in pain sensitivity. Nat Commun.
2014;5:2978. doi: 10.1038/ncomms3978. PMID: 24496475; PMCID: PMC3926001.
15: Grundberg E, Meduri E, Sandling JK, Hedman AK, Keildson S, Buil A, Busche S,
Yuan W, Nisbet J, Sekowska M, Wilk A, Barrett A, Small KS, Ge B, Caron M, Shin
SY; Multiple Tissue Human Expression Resource Consortium, Lathrop M, Dermitzakis
ET, McCarthy MI, Spector TD, Bell JT, Deloukas P. Global analysis of DNA
methylation variation in adipose tissue from twins reveals links to disease-
associated variants in distal regulatory elements. Am J Hum Genet. 2013 Nov
7;93(5):876-90. doi: 10.1016/j.ajhg.2013.10.004. Epub 2013 Oct 31. Erratum in:
Am J Hum Genet. 2013 Dec 5;93(6):1158. PMID: 24183450; PMCID: PMC3824131.
16: Glass D, Viñuela A, Davies MN, Ramasamy A, Parts L, Knowles D, Brown AA,
Hedman AK, Small KS, Buil A, Grundberg E, Nica AC, Di Meglio P, Nestle FO, Ryten
M; UK Brain Expression consortium; MuTHER consortium, Durbin R, McCarthy MI,
Deloukas P, Dermitzakis ET, Weale ME, Bataille V, Spector TD. Gene expression
changes with age in skin, adipose tissue, blood and brain. Genome Biol. 2013 Jul
26;14(7):R75. doi: 10.1186/gb-2013-14-7-r75. PMID: 23889843; PMCID: PMC4054017.
17: van Meurs JB, Pare G, Schwartz SM, Hazra A, Tanaka T, Vermeulen SH,
Cotlarciuc I, Yuan X, Mälarstig A, Bandinelli S, Bis JC, Blom H, Brown MJ, Chen
C, Chen YD, Clarke RJ, Dehghan A, Erdmann J, Ferrucci L, Hamsten A, Hofman A,
Hunter DJ, Goel A, Johnson AD, Kathiresan S, Kampman E, Kiel DP, Kiemeney LA,
Chambers JC, Kraft P, Lindemans J, McKnight B, Nelson CP, O'Donnell CJ, Psaty
BM, Ridker PM, Rivadeneira F, Rose LM, Seedorf U, Siscovick DS, Schunkert H,
Selhub J, Ueland PM, Vollenweider P, Waeber G, Waterworth DM, Watkins H,
Witteman JC, den Heijer M, Jacques P, Uitterlinden AG, Kooner JS, Rader DJ,
Reilly MP, Mooser V, Chasman DI, Samani NJ, Ahmadi KR. Common genetic loci
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Sjögren M, Smit JH, Snieder H, Soranzo N, Spector TD, Stenvinkel P, Sternberg
MJ, Swaminathan R, Tanaka T, Ubink-Veltmaat LJ, Uda M, Vollenweider P, Wallace
C, Waterworth D, Zerres K, Waeber G, Wareham NJ, Maxwell PH, McCarthy MI,
Jarvelin MR, Mooser V, Abecasis GR, Lightstone L, Scott J, Navis G, Elliott P,
Kooner JS. Genetic loci influencing kidney function and chronic kidney disease.
Nat Genet. 2010 May;42(5):373-5. doi: 10.1038/ng.566. Epub 2010 Apr 11. PMID:
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38: Rahmioğlu N, Ahmadi KR. Classical twin design in modern pharmacogenomics
studies. Pharmacogenomics. 2010 Feb;11(2):215-26. doi: 10.2217/pgs.09.171. PMID:
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39: Soranzo N, Rivadeneira F, Chinappen-Horsley U, Malkina I, Richards JB,
Hammond N, Stolk L, Nica A, Inouye M, Hofman A, Stephens J, Wheeler E, Arp P,
Gwilliam R, Jhamai PM, Potter S, Chaney A, Ghori MJ, Ravindrarajah R, Ermakov S,
Estrada K, Pols HA, Williams FM, McArdle WL, van Meurs JB, Loos RJ, Dermitzakis
ET, Ahmadi KR, Hart DJ, Ouwehand WH, Wareham NJ, Barroso I, Sandhu MS, Strachan
DP, Livshits G, Spector TD, Uitterlinden AG, Deloukas P. Meta-analysis of
genome-wide scans for human adult stature identifies novel Loci and associations
with measures of skeletal frame size. PLoS Genet. 2009 Apr;5(4):e1000445. doi:
10.1371/journal.pgen.1000445. Epub 2009 Apr 3. PMID: 19343178; PMCID:
PMC2661236.
40: McEvoy BP, Montgomery GW, McRae AF, Ripatti S, Perola M, Spector TD, Cherkas
L, Ahmadi KR, Boomsma D, Willemsen G, Hottenga JJ, Pedersen NL, Magnusson PK,
Kyvik KO, Christensen K, Kaprio J, Heikkilä K, Palotie A, Widen E, Muilu J,
Syvänen AC, Liljedahl U, Hardiman O, Cronin S, Peltonen L, Martin NG, Visscher
PM. Geographical structure and differential natural selection among North
European populations. Genome Res. 2009 May;19(5):804-14. doi:
10.1101/gr.083394.108. Epub 2009 Mar 5. PMID: 19265028; PMCID: PMC2675969.
41: Rahmioglu N, Andrew T, Cherkas L, Surdulescu G, Swaminathan R, Spector T,
Ahmadi KR. Epidemiology and genetic epidemiology of the liver function test
proteins. PLoS One. 2009;4(2):e4435. doi: 10.1371/journal.pone.0004435. Epub
2009 Feb 11. PMID: 19209234; PMCID: PMC2636884.
42: Crockford DJ, Maher AD, Ahmadi KR, Barrett A, Plumb RS, Wilson ID, Nicholson
JK. 1H NMR and UPLC-MS(E) statistical heterospectroscopy: characterization of
drug metabolites (xenometabolome) in epidemiological studies. Anal Chem. 2008
Sep 15;80(18):6835-44. doi: 10.1021/ac801075m. Epub 2008 Aug 14. Erratum in:
Anal Chem. 2008 Nov 1;80(21):8353. PMID: 18700783.
43: Richards JB, Rivadeneira F, Inouye M, Pastinen TM, Soranzo N, Wilson SG,
Andrew T, Falchi M, Gwilliam R, Ahmadi KR, Valdes AM, Arp P, Whittaker P,
Verlaan DJ, Jhamai M, Kumanduri V, Moorhouse M, van Meurs JB, Hofman A, Pols HA,
Hart D, Zhai G, Kato BS, Mullin BH, Zhang F, Deloukas P, Uitterlinden AG,
Spector TD. Bone mineral density, osteoporosis, and osteoporotic fractures: a
genome-wide association study. Lancet. 2008 May 3;371(9623):1505-12. doi:
10.1016/S0140-6736(08)60599-1. PMID: 18455228; PMCID: PMC2679414.
44: Chinappen-Horsley U, Blake GM, Fogelman I, Kato B, Ahmadi KR, Spector TD.
Quantitative trait loci for bone lengths on chromosome 5 using dual energy X-Ray
absorptiometry imaging in the Twins UK cohort. PLoS One. 2008 Mar 12;3(3):e1752.
doi: 10.1371/journal.pone.0001752. PMID: 18335030; PMCID: PMC2262137.
45: Zhang F, Kato BS, Gardner JP, Kimura M, Spector TD, Ahmadi KR. Lack of
association between leukocyte telomere length and genetic variants in two
ageing-related candidate genes. Mech Ageing Dev. 2007 Jul-Aug;128(7-8):415-22.
doi: 10.1016/j.mad.2007.05.007. Epub 2007 May 25. PMID: 17624411.
46: Zhang F, Zhai G, Kato BS, Hart DJ, Hunter D, Spector TD, Ahmadi KR.
Association between KLOTHO gene and hand osteoarthritis in a female Caucasian
population. Osteoarthritis Cartilage. 2007 Jun;15(6):624-9. doi:
10.1016/j.joca.2006.12.002. Epub 2007 Jan 30. PMID: 17270470.
47: Healy DG, Abou-Sleiman PM, Ahmadi KR, Gandhi S, Muqit MM, Bhatia KP, Quinn
NP, Lees AJ, Holton JL, Revesz T, Wood NW. NR4A2 genetic variation in sporadic
Parkinson's disease: a genewide approach. Mov Disord. 2006 Nov;21(11):1960-3.
doi: 10.1002/mds.21018. PMID: 16977628.
48: Need AC, Ahmadi KR, Spector TD, Goldstein DB. Obesity is associated with
genetic variants that alter dopamine availability. Ann Hum Genet. 2006 May;70(Pt
3):293-303. doi: 10.1111/j.1529-8817.2005.00228.x. PMID: 16674552.
49: Spector TD, Ahmadi KR, Valdes AM. When is a replication not a replication?
Or how to spot a good genetic association study. Arthritis Rheum. 2006
Apr;54(4):1051-4. doi: 10.1002/art.21730. PMID: 16572439.
50: Shah PR, Ahmad-Annuar A, Ahmadi KR, Russ C, Sapp PC, Horvitz HR, Brown RH
Jr, Goldstein DB, Fisher EM. No association of DYNC1H1 with sporadic ALS in a
case-control study of a northern European derived population: a tagging SNP
approach. Amyotroph Lateral Scler. 2006 Mar;7(1):46-56. doi:
10.1080/14660820500397057. PMID: 16546759.
51: Ozawa T, Healy DG, Abou-Sleiman PM, Ahmadi KR, Quinn N, Lees AJ, Shaw K,
Wullner U, Berciano J, Moller JC, Kamm C, Burk K, Josephs KA, Barone P, Tolosa
E, Goldstein DB, Wenning G, Geser F, Holton JL, Gasser T, Revesz T, Wood NW;
European MSA study group. The alpha-synuclein gene in multiple system atrophy. J
Neurol Neurosurg Psychiatry. 2006 Apr;77(4):464-7. doi:
10.1136/jnnp.2005.073528. PMID: 16543523; PMCID: PMC2077505.
52: Healy DG, Abou-Sleiman PM, Casas JP, Ahmadi KR, Lynch T, Gandhi S, Muqit MM,
Foltynie T, Barker R, Bhatia KP, Quinn NP, Lees AJ, Gibson JM, Holton JL, Revesz
T, Goldstein DB, Wood NW. UCHL-1 is not a Parkinson's disease susceptibility
gene. Ann Neurol. 2006 Apr;59(4):627-33. doi: 10.1002/ana.20757. PMID: 16450370.
53: Healy DG, Abou-Sleiman PM, Quinn N, Ahmadi KR, Ozawa T, Kamm C, Wullner U,
Oertel WH, Burk K, Dupont E, Pellecchia MT, Tolosa E, Gasser T, Holton JL,
Revesz T, Goldstein DB, Lees AJ, Wood NW; European MSA Study Group. UCHL-1 gene
in multiple system atrophy: a haplotype tagging approach. Mov Disord. 2005
Oct;20(10):1338-43. doi: 10.1002/mds.20575. PMID: 16007636.
54: Ahmadi KR, Weale ME, Xue ZY, Soranzo N, Yarnall DP, Briley JD, Maruyama Y,
Kobayashi M, Wood NW, Spurr NK, Burns DK, Roses AD, Saunders AM, Goldstein DB. A
single-nucleotide polymorphism tagging set for human drug metabolism and
transport. Nat Genet. 2005 Jan;37(1):84-9. doi: 10.1038/ng1488. Epub 2004 Dec
19. PMID: 15608640.
55: Healy DG, Abou-Sleiman PM, Ahmadi KR, Muqit MM, Bhatia KP, Quinn NP, Lees
AJ, Latchmann DS, Goldstein DB, Wood NW. The gene responsible for PARK6
Parkinson's disease, PINK1, does not influence common forms of parkinsonism. Ann
Neurol. 2004 Sep;56(3):329-35. doi: 10.1002/ana.20206. PMID: 15349859.
56: Goldstein DB, Cavalleri GL, Ahmadi KR. The genetics of common diseases: 10
million times as hard. Cold Spring Harb Symp Quant Biol. 2003;68:395-401. doi:
10.1101/sqb.2003.68.395. PMID: 15338641.
57: Healy DG, Abou-Sleiman PM, Jain S, Ahmadi KR, Wood NW. Assessment of a DJ-1
(PARK7) polymorphism in Finnish PD. Neurology. 2004 Jun 22;62(12):2335. doi:
10.1212/wnl.62.12.2335-a. PMID: 15210917.
58: Healy DG, Abou-Sleiman PM, Ozawa T, Lees AJ, Bhatia K, Ahmadi KR, Wullner U,
Berciano J, Moller JC, Kamm C, Burk K, Barone P, Tolosa E, Quinn N, Goldstein
DB, Wood NW. A functional polymorphism regulating dopamine beta-hydroxylase
influences against Parkinson's disease. Ann Neurol. 2004 Mar;55(3):443-6. doi:
10.1002/ana.20063. Erratum in: Ann Neurol. 2004 Aug;56(2):311. Barrone P
[corrected to Barone P]. PMID: 14991826.
59: Goldstein DB, Ahmadi KR, Weale ME, Wood NW. Genome scans and candidate gene
approaches in the study of common diseases and variable drug responses. Trends
Genet. 2003 Nov;19(11):615-22. doi: 10.1016/j.tig.2003.09.006. PMID: 14585613.
60: Ahmadi KR, Lanchbury JS, Reed P, Chiano M, Thompson D, Galley M, Line A,
Lank E, Wong HJ, Strachan D, Spector TD. Novel association suggests multiple
independent QTLs within chromosome 5q21-33 region control variation in total
humans IgE levels. Genes Immun. 2003 Jun;4(4):289-97. doi:
10.1038/sj.gene.6363968. PMID: 12761566.
61: Ahmadi KR, Goldstein DB. Multifactorial diseases: asthma genetics point the
way. Curr Biol. 2002 Oct 15;12(20):R702-4. doi: 10.1016/s0960-9822(02)01211-3.
PMID: 12401189.
62: Ahmadi KR, Hall MA, Norman P, Vaughan RW, Snieder H, Spector TD, Lanchbury
JS. Genetic determinism in the relationship between human CD4+ and CD8+ T
lymphocyte populations? Genes Immun. 2001 Nov;2(7):381-7. doi:
10.1038/sj.gene.6363796. PMID: 11704804.
63: Hall MA, Ahmadi KR, Norman P, Snieder H, MacGregor AJ, Vaughan RW, Spector
TD, Lanchbury JS. Genetic influence on peripheral blood T lymphocyte levels.
Genes Immun. 2000 Oct;1(7):423-7. doi: 10.1038/sj.gene.6363702. PMID: 11196672.