Isaiah Joseph Ting
About
My research project
Co-expression of Ultradian and Circadian rhythms Investigation of co-expression of ultradian and circadian rhythms in biological data is vital to add knowledge to the behaviours of these rhythms. Using both in vitro (cell culture) and in silico (signal processing, MATLAB) methods, this project aims to expose ultradian rhythms and enhance its detection within in vitro models as well as pre-existing biological data.
Supervisors
Investigation of co-expression of ultradian and circadian rhythms in biological data is vital to add knowledge to the behaviours of these rhythms. Using both in vitro (cell culture) and in silico (signal processing, MATLAB) methods, this project aims to expose ultradian rhythms and enhance its detection within in vitro models as well as pre-existing biological data.
University roles and responsibilities
- STARS Undergraduate Mentor
- FHMS Associate Theme Champion (Chronobiology and Sleep)
- FHMS laboratory demonstrator
- EDI PGR Representative
My qualifications
Affiliations and memberships
ResearchResearch interests
1. Co-expression of biological rhythms (ultradian and circadian).
2. Unmasking biological co-expression of stated rhythms.
3. Relationship between metabolism and biological rhythm, specifically with ultradian rhythms.
4. Biomedical signal processing.
Research interests
1. Co-expression of biological rhythms (ultradian and circadian).
2. Unmasking biological co-expression of stated rhythms.
3. Relationship between metabolism and biological rhythm, specifically with ultradian rhythms.
4. Biomedical signal processing.
Teaching
Assists with undergraduate final year projects alongside Dr. Van der Veen.
Publications
Highlights
The Lost Connection Between the Filipino People and our Past - the Effects of Colonialism in this Generation By Isaiah Ting and Hazel Ting
I Can Speak English, You Know By Isaiah Ting
Thermosensitive hydrogels have been studied as feasible needle-avoidance alternative to vaccine delivery. In this work, we report the development of a new thermal-sensitive hydrogel for intranasal vaccine delivery. This delivery system was formulated with a combination of the polymer Gantrez® AN119 and the surfactant Pluronic® F127 (PF127), with a high biocompatibility, biodegradability and immunoadjuvant properties. Shigella flexneri outer membrane vesicles were used as the antigen model. A stable and easy-to-produce thermosensitive hydrogel which allowed the incorporation of the OMV-antigenic complex was successfully synthetized. A rapid gel formation was achieved at body temperature, which prolonged the OMV-antigens residence time in the nasal cavity of BALB/c mice when compared to intranasal delivery of free-OMVs. In addition, the bacterial antigens showed a fast release profile from the hydrogel in vitro, with a peak at 30 min of incubation at 37 °C. Hydrogels appeared to be non-cytotoxic in the human epithelial HeLa cell line and nose epithelium as well, as indicated by the absence of histopathological features. Immunohistochemical studies revealed that after intranasal administration the OMVs reached the nasal associated lymphoid tissue. These results support the use of here described thermosensitive hydrogels as a potential platform for intranasal vaccination.