Dr Ioannis Smyrnias
Lecturer in Molecular and Cellular Sciences
BSc (Hons), MRes, PhD
About
Biography
ResearchResearch interests
We study the mechanisms via which cardiomyocytes sense and respond to conditions of stress to restore cellular homeostasis and protect the failing heart.
Our main research interests are to identify the mechanisms that mediate and regulate the mitochondrial unfolded protein response (UPRmt). We recently demonstrated the protective effects of the UPRmt in the stressed heart; however, our current knowledge of the signalling cascades that underpin this UPRmt-mediated protection in cardiac pathophysiology is limited.
Research interests
We study the mechanisms via which cardiomyocytes sense and respond to conditions of stress to restore cellular homeostasis and protect the failing heart.
Our main research interests are to identify the mechanisms that mediate and regulate the mitochondrial unfolded protein response (UPRmt). We recently demonstrated the protective effects of the UPRmt in the stressed heart; however, our current knowledge of the signalling cascades that underpin this UPRmt-mediated protection in cardiac pathophysiology is limited.
Publications
Ioannis Smyrnias, Stephen P. Gray, Darlington O. Okonko, Greta Sawyer, Anna Zoccarato, Norman Catibog, Begoña López, Arantxa González, Susana Ravassa, Javier Díez, Ajay M. Shah (2019) Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload - JACC
I. Smyrnias (2021) The mitochondrial unfolded protein response and its diverse roles in cellular stress - IJBCB
Ioannis Smyrnias, Normann Goodwin, Dagmar Wachten, Jonas Skogestad, Jan Magnus Aronsen, Emma L Robinson, Kateryna Demydenko, Anne Segonds-Pichon, David Oxley, Sakthivel Sadayappan, Karin Sipido, Martin D Bootman, H Llewelyn Roderick (2018) Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes - JMCC
Ioannis Smyrnias, Xiaohong Zhang, Min Zhang, Thomas V A Murray, Ralf P Brandes, Katrin Schröder, Alison C Brewer, Ajay M Shah (2015) Nicotinamide adenine dinucleotide phosphate oxidase-4-dependent upregulation of nuclear factor erythroid-derived 2-like 2 protects the heart during chronic pressure overload - Hypertension