Ellie Miles
Academic and research departments
Section of Sport, Health and Exercise Sciences, School of Biosciences.About
My research project
Investigating and modifying the physiological processes associated with premature frailty and physical dysfunction in adults with chronic lymphocytic leukaemiaChronic Lymphocytic Leukaemia (CLL) is the most prevalent adult Leukaemia in the western world, predominantly affecting the older population. It is a disease that differs from other cancers in that most have a period of no treatment lasting years before treatment is initiated. Due to age-related and cancer-specific complications, individuals with CLL are at an increased risk of frailty, often characterised physiologically by physical dysfunction. Exercise may improve physical function in solid tumours and other haematological malignancies. However, only one study has assessed the role of exercise training specifically within CLL, identifying the feasibly of an exercise intervention within this population. Therefore, the aims for this project are to explore the physiological processes associated with premature frailty within Chronic Lymphocytic Leukemia, and to identify how these processes may change with the addition of supervised and semi-supervised exercise. I hope that the findings from my project will provide further insight into the role of exercise within this clinical population and provide guidance to practitioners when advising patients on exercise.
Supervisors
Chronic Lymphocytic Leukaemia (CLL) is the most prevalent adult Leukaemia in the western world, predominantly affecting the older population. It is a disease that differs from other cancers in that most have a period of no treatment lasting years before treatment is initiated. Due to age-related and cancer-specific complications, individuals with CLL are at an increased risk of frailty, often characterised physiologically by physical dysfunction. Exercise may improve physical function in solid tumours and other haematological malignancies. However, only one study has assessed the role of exercise training specifically within CLL, identifying the feasibly of an exercise intervention within this population. Therefore, the aims for this project are to explore the physiological processes associated with premature frailty within Chronic Lymphocytic Leukemia, and to identify how these processes may change with the addition of supervised and semi-supervised exercise. I hope that the findings from my project will provide further insight into the role of exercise within this clinical population and provide guidance to practitioners when advising patients on exercise.