Born to die young: The early death of nerve cells is crucial to form healthy brains

Scientists have long tried to better understand how the cerebral cortex and its layers develop, with pathologies such as autism, schizophrenia and epilepsy linked to this process.

In a paper published by the journal Cerebral Cortex, scientists from Surrey, Newcastle University, and Nottingham University detail how they developed and used a computational model to simulate cell division, cell migration and apoptosis (cell death) in the hope of understanding how these processes affect the development of the brain.

With the help of their computer model, the researchers reproduced a wide number of cerebral structures to study – from rats to macaques, to humans.  

The team also observed that slight changes in how cells perform division and apoptosis lead to the development of cortical structures found in neurodevelopmental disorders such as autism, polymicrogyria and subcortical band heterotopia.

Dr Roman Bauer, Engineering and Physical Sciences Research Council Research Fellow and lead author of the study from the University of Surrey, said: “We are working towards a comprehensive computational model of the cerebral cortex and how it develops – taking into account how neurons behave and organise themselves in our brains. It is clear to us that computational models have a crucial role to play in helping us to comprehensively understand the complex biological processes that lead to developmental disorders.”

Marcus Kaiser, Professor of Neuroinformatics at the University of Nottingham and senior author of the study, said: “A large proportion of nerve cells dies before birth, but it was unclear why these cells are just born to die at such an early stage. The team’s results showed that cell death plays an essential role in developing the brain, as it influences the thickness of the cortex’s layers, variety and layer cell density.”



To find out more read the full study.