Sustainable bioactive 3D scaffolds for bone regeneration prepared via 3D printing: manufacturing, bioactivity and biocompatibility

Applications are invited to apply for a 3.5 year EPSRC funded PhD studentship on the development of a novel injectable bioink (phosphate-gel based) for production of regenerative 3D bone scaffolds.

Bone constructs manufactured via bioprinting represent a tremendous improvement in the quality life of patients. Bioinks (biomaterials for bioprinting) are an important aspect of the bioprinting process as they provide a suitable environment for cells and structural support. 

The overall aim of this interdisciplinary PhD project proposal is to use 3D printing and bioprinting to accurately reproduce the structure of natural bone tissue by mimicking its structural, mechanical and bioactive properties. The techniques of sol-gel chemistry and coacervation will be used to manufacture the precursor gel which will be then 3D printed to produce a phosphate-based amorphous scaffold.

Structural and morphological characterisation of the glasses and scaffolds will be investigated using a multi-technique approach involving electron microscopy (SEM and TEM), thermal analysis, physisorption, X-ray diffraction, and X-ray absorption spectroscopy at synchrotron radiation facilities. Cytocompatibility will be assessed on osteoblasts via MTT testing. 

Spanning across materials science, chemistry, biology and medicine, this proposal is truly multidisciplinary. The PhD candidate will develop a range of complementary skills in fabrication (3D printing, electrospinning), cell culture and cutting-edge characterisation techniques.

Open to any UK or international candidates. Up to 30% of our UKRI funded studentships can be awarded to candidates paying international rate fees.

You will need to meet the minimum entry requirements for our PhD programme.

PhD candidates must have a first class or 2:1 degree (or equivalent) in a relevant scientific discipline, including Biomaterial Science, Chemistry, Physics, Chemical Engineering and Material Science and a strong interest in bio/nanomaterials.