Platelets and cancer: identifying novel interactions and therapeutic targets to prevent disease

Platelets are tiny circulating blood cells which prevent bleeding from damaged blood vessels (haemostasis) by becoming active at the site of injury. In addition to this crucial role, platelets can be activated inappropriately (thrombosis) leading to heart attack or stroke. Platelets also contribute to the progression of other diseases such as inflammation, cancer, or diabetes through the secretion of bioactive substances and microparticles which influence the activity of many different cell types.

Thrombotic complications are commonly seen in cancer patients and are a leading cause of death in these patients. This exciting new project aims to explore how platelets regulate cancer cell activity. The successful student will investigate how platelet-released substances interact with receptors on the surface of cancer cells, how this leads to the formation of tumour cell-platelet aggregates and will explore if this can be targeted to reduce cancer metastasis and develop better therapies.

This project will equip the student with skills in a wide range of techniques including the use of specialist tests of platelet function, cell migration, cell and molecular biology assays, mass spectrometry and microscopy.

Applicants should have a first-class or upper second-class honours or equivalents in Biochemistry, Biomedical Sciences, Biomedical Engineering, Biological Sciences, Physiology or similar subjects.

Practical experience of cell biology, platelet or cancer cell biology is desirable but not essential.

English language requirements

IELTS Academic 6.5 or above (or equivalent) with at least 6.0 in each individual category, or equivalent.