New tools for sustainable control of liver fluke in ruminants (FoodBioSystems DTP)

Food producing animals are infected by multiple species of parasites, which severely compromise their health and productivity. The liver fluke Fasciola hepatica is amongst the most common and highly pathogenic parasites of cattle and sheep in many parts of the UK. Control of this parasite involves strategic treatment of ruminants with flukicides (drugs which kill flukes), guided by “fluke forecasts” which predict risk of liver fluke infection based on climate data. However, resistance is emerging to the most widely used flukicide, posing a severe threat to sustainable liver fluke control. Meanwhile, current fluke forecasts are based on old data and there is limited information available to validate new models, so new methods of tracking fluke populations are needed.

This PhD project aims to generate and use genomic data from liver fluke to develop a large panel of novel genetic markers for this parasite. These markers will be used to analyse seasonal variations in liver fluke population structure in sheep and cattle in different geographical locations in the UK, providing important insights into disease burden, infection transmission and the potential for emergence and spread of flukicide resistance. In addition, new “fluke forecasting” models will be developed and tested using data collected during the project, including parasite genetic data. This will enable better predictions of when and where liver fluke infection is likely to occur, leading to improved and sustainable control of this parasite, and ultimately better livestock health and productivity.

About the FoodBioSystems DTP

The FoodBioSystems Doctoral Training Partnership (DTP) brings together six university partners: University of Reading, Cranfield University, University of Surrey, Queen’s University Belfast, Aberystwyth University, and Brunel University London. The Partnership’s vision is to develop the next generation of bioscientists with in-depth knowledge and technical expertise of food systems and biological processes across the Agri-Food system from pre-farm to post-fork. They will become the urgently needed experts - able to transform the food value chain and address challenges of sustainability, efficacy, authenticity and safety in food production systems whilst delivering better nutrition and concomitant health benefits for society. The DTP is currently advertising 36 projects. From these, it is expected 24 studentships will be awarded to the strongest application to start their studies in October 2022.

This project would be suitable for students with a veterinary degree or a degree in biological sciences or a quantitative disciplines such as mathematics, physics or engineering. Demonstrated interest in the topic, for example through prior experience of working with parasites or related pathogens would be beneficial. Some experience of molecular laboratory settings, for example through undergraduate projects or placements, would be helpful. As the project involves genomics analysis and modelling components, demonstrated ability in these areas and interest in the use of those approaches would be advantageous.

This studentship is available for UK and international students.

IELTS requirements: The standard requirement is for a score of 6.5 or above (or equivalent) with 6.0 in each individual category, in an IELTS Academic test taken in the last 2 years. 

Department of Nutritional Sciences.

References

• https://doi.org/10.1016/j.parint.2020.102071
• https://doi.org/10.1098/rsif.2018.0072
• https://www.research.ed.ac.uk/en/publications/a-high-throughput-deep-amplicon-sequencing-method-toshow-the-eme.