Fully Funded British Heart Foundation PhD Studentship in ‘Cellular and molecular mechanisms of atrial fibrillation’

Applications are invited for a 3-year, fully funded British Heart Foundation PhD studentship within the Cardiovascular Research Group at the University of Surrey. We are internationally recognised for our work on cardiac diseases and offer state-of-the-art facilities and cutting-edge technologies. The student will join a multidisciplinary team and benefit from a full programme of training in research and transferable skills organised by our Doctoral Training Centre. 

Project Description

Atrial fibrillation (AF) is a common disease in which the upper chambers of the heart (atria) do not contract in synchrony with the rest of the heart. AF can reduce the heart's efficiency at pumping blood and can lead to several cardiovascular diseases including stroke, myocardial infarction, and sudden cardiac death. The causes of AF are not fully understood but relate to disruptions in the electrical impulses which stimulate atrial contraction. The atria consist of contractile myocytes and supporting fibroblasts, however how the communication between these two cell types affects the function of the atria and the initiation/progression of AF remains largely unexplored. This project will investigate the functional and molecular communication between atrial cells using engineered cardiac tissue generated from human induced pluripotent stem cells. The successful candidate will be trained in relevant methods and procedures, including cell culture, cardiac electrophysiology, molecular biology/protein isolation and characterization, advanced microscopy, and multi-omics.

The University of Surrey is located on a beautiful, leafy campus in Guildford, just 30 miles from London and benefitting from excellent rail and road connections.

You will need to meet the minimum entry requirements for our Biosciences and Medicine PHD programme.

Open to candidates who pay UK/home rate fees. See UKCISA for further information.

Applicants should hold (or be about to obtain) a first or upper second class honours degree (or equivalent) in a relevant subject area including; medical sciences, biomedical sciences, biomedical engineering, molecular biology, physiology, biochemistry or related disciplines. 

Self-motivation, deep interest in research, ability to think and work independently, fluency in English language and good oral and written communication skills are essential.

An MSc in cardiovascular/molecular science with merit or distinction and/or previous research experience in molecular biology or physiology would be advantageous.