Dr Raphaelle Winsky-Sommerer
Senior Lecturer in Sleep & Circadian Rhythms
Qualifications: BSc, MSc, PhD, Dr. Habil.
Phone: Work: 01483 68 9671
Senior Lecturer in Sleep & Circadian Rhythms (since April 2012)
Faculty of Health and Medical Sciences, University of Surrey, UK.
Lecturer in Sleep & Circadian Rhythms (October 2009)
Faculty of Health and Medical Sciences, University of Surrey, UK.
Research Associate in Sleep & Chronobiology (2004-2009)
Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.
Post-doctoral Research Fellow in Neuroscience (2002-2004)
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.
Ph.D. Cellular & Molecular Biology, Biology of Ageing (1998-2002)
University of René Descartes Paris 5, France. INSERM U549, Paris, France.
Master in Biochemistry & Biology of Ageing (1996-1998)
(Master I in Biochemistry; Master II = French DEA in Biology of Ageing)
University of Paris 5 & 7, France.
Bachelor of Science in Biochemistry (1994-1996)
University of Paris 7, France.
Sleep & Circadian Rhythms – Pharmacology of Sleep and Wakefulness
Cellular and molecular mechanisms underlying the regulation of the daily sleep-wake cycle; Hypnotics and wake-promoting compounds.
Physiology of Neurotransmitter & Neuropeptide Systems
GABAergic transmission and GABAA receptors; adenosinergic system; neuropeptides (i.e., hypocretins/orexins, corticotrophin-releasing hormone, somatostatin/cortistatin, vasopressin, oxytocin).
Disorders of the Central Nervous System - Aging
Insomnia; Stress; Addiction; Aging; Neurodegenerative diseases (i.e., Alzheimer’s disease)
- New Investigator Research Grant- British Biotechnology and Biological Sciences Research Council; BB/I008926/1; 2011-2014; £494,741; 36 months; to R. Winsky-Sommerer (PI).
- Investigator-initiated Research Grant- Pharmaceutical Company; £157,745; 12 months; to R. Winsky-Sommerer (PI), D-J Dijk, S. Archer.
- Feasibility Study Grant- MILES (Models and Mathematics in Life and Social Sciences) University of Surrey; £11,561; to K. Wells, A. Hilton, J. Kilner, R. Winsky-Sommerer.
- Sponsor Award- Grant Seminar Competition 2010-2011, Institute of Advanced Studies, University of Surrey; £2,500 to R. Winsky-Sommerer & D-J Dijk. Two-day international workshop “Multidisciplinary Dissection of Sleep Phenotypes in Animals and Humans”, July 13-14, 2011
- University of Surrey.Research Grant- Forschungskredit 2007 University of Zurich; FK2007#54321101; 2007-2009; CHF100,000; 24 months; to R. Winsky-Sommerer (PI).
- Award for Outstanding Basic Sleep Research 2009- Swiss Society of Sleep Research, Sleep Medicine and Chronobiology.
- 'The oxytocin analogue carbetocin prevents emotional impairment and stress-induced reinstatement of opioid-seeking in morphine-abstinent mice'. Neuropsychopharmacology, 39 (4), pp. 855-865.doi: 10.1038/npp.2013.285
- 'The Oxytocin Analogue Carbetocin Prevents Emotional Impairment and Stress-Induced Reinstatement of Opioid-Seeking in Morphine-Abstinent Mice.'. Neuropsychopharmacology, doi: 10.1038/npp.2013.285
- 'Chronic methamphetamine treatment induces oxytocin receptor up-regulation in the amygdala and hypothalamus via an adenosine A receptor-independent mechanism'. Pharmacology Biochemistry and Behavior, . (2013)
- 'Somatostatin/Cortistatin'. Handbook of Biologically Active Peptides, , pp. 933-942. . (2013)
- 'Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep, and EEG Power Spectra in a Model of Situational Insomnia.'. Nature Neuropsychopharmacology, England: 37 (5), pp. 1224-1233.doi: 10.1038/npp.2011.310Full text is available at: http://epubs.surrey.ac.uk/286648/
Orexins have a role in sleep regulation, and orexin receptor antagonists are under development for the treatment of insomnia. We conducted a randomised, double-blind, placebo-controlled, four-period crossover study to investigate the effect of single doses of the dual orexin receptor antagonist SB-649868 (10 or 30 mg) and a positive control zolpidem (10 mg), an allosteric modulator of GABA(A) receptors. Objective and subjective sleep parameters and next-day performance were assessed in 51 healthy male volunteers in a traffic noise model of situational insomnia. Compared with placebo, SB-649868 10 and 30 mg increased total sleep time (TST) by 17 and 31 min (p<0.001), whereas after zolpidem TST was increased by 11.0 min (p=0.012). Wake after sleep onset was reduced significantly by 14.7 min for the SB-6489698 30 mg dose (p<0.001). Latency to persistent sleep was significantly reduced after both doses of SB-6489698 (p=0.003), but not after zolpidem. Slow wave sleep (SWS) and electroencephalogram (EEG) power spectra in non-REM sleep were not affected by either dose of SB-640868, whereas SWS (p< 0.001) and low delta activity (<=1.0 Hz) were increased, and 2.25-11.0 Hz activity decreased after zolpidem. REM sleep duration was increased after SB-649868 30 mg (p=0.002) and reduced after zolpidem (p=0.049). Latency to REM sleep was reduced by 20.1 (p=0.034) and 34.0 min (p<0.001) after 10 and 30 mg of SB-649868. Sleep-onset REM episodes were observed. SB-649868 was well tolerated. This dual orexin receptor antagonist exerts hypnotic activity, with effects on sleep structure and the EEG that are different from those of zolpidem.
- 'Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia'. Neuropsychopharmacology, 37 (5), pp. 1224-1233.doi: 10.1038/npp.2011.310
- 'Sleep: The way we snooze now'. New Scientist, 213 (2850) . (2012)
- 'Sleep: How much we need and what keeps us awake'. New Scientist, 213 (2850) . (2012)
- 'Sleep: Moving to a 24/7 society'. New Scientist, 213 (2850) . (2012)
- 'Sleep: What it is and what it's for'. New Scientist, 213 (2850) . (2012)
- 'Altered sleep and behavioral activity phenotypes in PER3-deficient mice.'. Am J Physiol Regul Integr Comp Physiol, . (2011)
- 'Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens.'. Society for Neuroscience J Neurosci, United States: 31 (27), pp. 10067-10075.Full text is available at: http://epubs.surrey.ac.uk/285503/
Caffeine, the most widely used psychoactive compound, is an adenosine receptor antagonist. It promotes wakefulness by blocking adenosine A(2A) receptors (A(2A)Rs) in the brain, but the specific neurons on which caffeine acts to produce arousal have not been identified. Using selective gene deletion strategies based on the Cre/loxP technology in mice and focal RNA interference to silence the expression of A(2A)Rs in rats by local infection with adeno-associated virus carrying short-hairpin RNA, we report that the A(2A)Rs in the shell region of the nucleus accumbens (NAc) are responsible for the effect of caffeine on wakefulness. Caffeine-induced arousal was not affected in rats when A(2A)Rs were focally removed from the NAc core or other A(2A)R-positive areas of the basal ganglia. Our observations suggest that caffeine promotes arousal by activating pathways that traditionally have been associated with motivational and motor responses in the brain.
- 'Persistent brain region-specific upregulation of vasopressin (V1ar) and oxytocin receptors in chronic intermittent escalating dose morphine administration in mice'. POLISH ACAD SCIENCES INST PHARMACOLOGY PHARMACOL REP, 63 (1), pp. 252-252. . (2011)
- 'Manipulation of Adenosine Kinase Affects Sleep Regulation in Mice'. SOC NEUROSCIENCE JOURNAL OF NEUROSCIENCE, 30 (39), pp. 13157-13165.Full text is available at: http://epubs.surrey.ac.uk/285504/
- 'Role of GABA(A) receptors in the physiology and pharmacology of sleep'. WILEY-BLACKWELL EUROPEAN JOURNAL OF NEUROSCIENCE, 29 (9), pp. 1779-1794.Full text is available at: http://epubs.surrey.ac.uk/286630/
- 'Mechanisms Underlying the Effects of GABAA Sedative-Hypnotic Drugs'. KARGER NEUROPSYCHOBIOLOGY, 59 (4), pp. 248-249.doi: 10.1159/000230666
- 'Sleep Deprivation in the Dark Period Does Not Impair Memory in OF1 Mice'. TAYLOR & FRANCIS INC CHRONOBIOL INT, 26 (4), pp. 682-696.Full text is available at: http://epubs.surrey.ac.uk/375307/
There is increasing evidence that sleep facilitates memory acquisition and consolidation. Moreover, the sleep-wake history preceding memory acquisition and retention as well as circadian timing may be important. We showed previously that sleep deprivation (SD) following learning in OF1 mice impaired their performance on an object recognition task. The learning task was scheduled at the end of the 12 h dark period and the test 24 h later. To investigate the influence of the prominent circadian sleep-wake distribution typical for rodents, we now scheduled the learning task at the beginning of the dark period. Wakefulness following immediately after the learning task was attained either by gentle interference (SD; n = 20) or by spontaneous wheel running (RW; n = 20). Two control groups were used: one had no RW throughout the experiment (n = 23), while the other group's wheel was blocked immediately after acquisition (n = 16), thereby preventing its use until testing. Recognition memory, defined as the difference in exploration of a novel and of familiar objects, was assessed 24 h later during the test phase. Motor activity and RW use were continuously recorded. Remarkably, performance on the object recognition task was not influenced by the protocols; the waking period following acquisition did not impair memory, independent of the method inducing wakefulness (i.e., sleep deprivation or spontaneous running). Thus, all groups explored the novel object significantly longer than the familiar ones during the test phase. Interestingly, neither the amount of rest lost during the SD interventions nor the amount of rest preceding acquisition influenced performance. However, the total amount of rest obtained by the control and SD mice subjected to acquisition at “dark offset” correlated positively (r = 0.66) with memory at test, while no such relationship occurred in the corresponding groups tested at dark onset. Neither the amount of running nor intermediate rest correlated with performance at test in the RW group. We conclude that interfering with sleep during the dark period does not affect object recognition memory consolidation.
- 'Sleep Regulation in Mice with Adenosine Metabolism Deficiency'. KARGER NEUROPSYCHOBIOLOGY, 59 (4), pp. 261-262.doi: 10.1159/000230666
- 'Normal sleep homeostasis and lack of epilepsy phenotype in GABA(A) receptor alpha 3 subunit-knockout mice'. PERGAMON-ELSEVIER SCIENCE LTD NEUROSCIENCE, 154 (2), pp. 595-605.Full text is available at: http://epubs.surrey.ac.uk/285507/
- 'Alteration of behavior in mice by muscimol is associated with regional electroencephalogram synchronization'. PERGAMON-ELSEVIER SCIENCE LTD NEUROSCIENCE, 147 (3), pp. 833-841.Full text is available at: http://epubs.surrey.ac.uk/286646/
- 'The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABA(A) delta-subunit-containing receptors'. WILEY-BLACKWELL EUROPEAN JOURNAL OF NEUROSCIENCE, 25 (6), pp. 1893-1899.Full text is available at: http://epubs.surrey.ac.uk/286620/
- 'Transgenic mice with a reduced core body temperature have an increased life span'. AMER ASSOC ADVANCEMENT SCIENCE SCIENCE, 314 (5800), pp. 825-828. . (2006)
- 'Sleep deprivation impairs object recognition in mice'. ACADEMIC PRESS INC ELSEVIER SCIENCE NEUROBIOLOGY OF LEARNING AND MEMORY, 85 (3), pp. 263-271.Full text is available at: http://epubs.surrey.ac.uk/375306/
- 'Brain Somatostatin-Related Peptides'. Handbook of Biologically Active Peptides, , pp. 645-654. . (2006)
- 'Stress and arousal - The corticotrophin-releasing factor/hypocretin circuitry'. HUMANA PRESS INC MOL NEUROBIOL, 32 (3), pp. 285-294. . (2005)
- 'Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain'. WILEY-LISS JOURNAL OF COMPARATIVE NEUROLOGY, 490 (2), pp. 119-132.doi: 10.1002/cne.20656
- 'Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 288 (6), pp. R1727-R1732. . (2005)
- 'The corticotropin-releasing factor-hypocretin connection: Implications in stress response and addiction'. PROUS SCIENCE, SA DRUG NEWS PERSPECT, 18 (4), pp. 250-255. . (2005)
- 'Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity'. BLACKWELL PUBLISHING LTD JOURNAL OF NEUROCHEMISTRY, 93 (2), pp. 493-501. . (2005)
- 'Interaction between the corticotropin-releasing factor system and hypocretins (Orexins): A novel circuit mediating stress response'. SOC NEUROSCIENCE JOURNAL OF NEUROSCIENCE, 24 (50), pp. 11439-11448. . (2004)
- 'Overexpression of the human beta-amyloid precursor protein downregulates cortistatin mRNA in PDAPP mice'. ELSEVIER SCIENCE BV BRAIN RESEARCH, 1023 (1), pp. 157-162. . (2004)
- 'The role of the hypcretinergic system in the integration of networks that dictate the states of arousal'. PROUS SCIENCE, SA DRUG NEWS PERSPECT, 16 (8), pp. 504-512. . (2003)
- 'The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease'. PERGAMON-ELSEVIER SCIENCE LTD NEUROSCIENCE, 122 (2), pp. 437-447. . (2003)
- 'Comparison of somatostatin receptor expression in human gliomas and medulloblastomas'. BLACKWELL PUBLISHING LTD JOURNAL OF NEUROENDOCRINOLOGY, 14 (6), pp. 458-471. . (2002)
- 'Loss of somatostatin-like immunoreactivity in the frontal cortex of Alzheimer patients carrying the apolipoprotein epsilon 4 allele'. ELSEVIER SCI IRELAND LTD NEUROSCIENCE LETTERS, 255 (1), pp. 21-24. . (1998)
- 'Investigating the possible usefulness of Lempel-Ziv complexity for the characterisation of electroencephalogram sleep recordings'. Final Programme and Book of Abstracts of BioDynamics 2013, Bristol, UK: BioDynamics 2013 - Rhythms in biological systems, pp. 24-25. . (2013)
- 'Sleep in transgenic mouse models for a polymorphism in the human PER3 gene'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 79-79. . (2012)
- 'Role of the GABAA Alpha4-Subtype in Sleep and Sleep Regulation'. Neuropsychobiology: international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, biological psychology, pharmacopsychology and pharmacoelectroencephalography, Annual Conference of Swiss Society of Sleep Research, Sleep Medicine and Chronobiology 4 (59), pp. 267-267.doi: 10.1159/000230666)
- 'DECIPHERING THE ROLE OF THE GABA-A ALPHA4-SUBTYPE IN SLEEP'. AMER ACAD SLEEP MEDICINE SLEEP, Seattle, WA: 23rd Annual Meeting of the Associated-Professional-Sleep-Societies 32, pp. A14-A15. . (2009)
- 'New insights from basic animal research on GABAA receptor mediated inhibition to understand selective pharmacological profiles of hypnotics'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 58-58. . (2008)
- 'A role for GABAA alpha 4-subunit-containing receptors in sleep regulation?'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 203-204. . (2008)
- 'Sleep and sleep regulation in mice lacking the GABA-A receptor A3-subunit'. AMER ACAD SLEEP MEDICINE SLEEP, Baltimore, MD: 22nd Annual Meeting of the Associated-Professional-Sleep-Societies 31, pp. A17-A18. . (2008)
- 'Evidence for mechanism of action of the GABA-A receptor agonist THIP in GABA-A receptor delta subunit knockout mice'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 238-238. . (2006)
- 'Effects of the GABA-A receptor agonist THIP on the sleep EEG of GABA-A receptor delta subunit knockout mice'. AMER ACADEMY SLEEP MEDICINE SLEEP, Salt Lake City, UT: 20th Annual Meeting of the Associated-Professional-Sleep-Societies 29, pp. A21-A21. . (2006)
- 'A key role for hypocretin in regulating brain reward function and reinstatement for drug-seeking behavior in rats'. LIPPINCOTT WILLIAMS & WILKINS BEHAVIOURAL PHARMACOLOGY, Barcelona, SPAIN: 11th Biennial Meeting of the European-Behavioral-Pharmacology-Society 16, pp. S60-S60. . (2005)
- 'Neuropeptide S projects to arousal nuclei'. AMER ACADEMY SLEEP MEDICINE SLEEP, Denver, CO: 19th Annual Meeting of the Associated-Professional-Sleep-Societies 28, pp. A10-A10. . (2005)
- 'Effects of neuropeptide S in the regulation of sleep-wake cycle'. AMER ACADEMY SLEEP MEDICINE SLEEP, Philadelphia, PA: 18th Annual Meeting of the Associated-Professional-Sleep-Societies 27, pp. 32-33. . (2004)
- 'Interaction between the corticotropin-releasing-factor system and hypocretins: Components mediating the stress response'. AMER ACADEMY SLEEP MEDICINE SLEEP, Philadelphia, PA: 18th Annual Meeting of the Associated-Professional-Sleep-Societies 27, pp. 23-23. . (2004)
- 'Effects of urotensin-II in the regulation of REM sleep'. AMER ACADEMY SLEEP MEDICINE SLEEP, CHICAGO, ILLINOIS: 17th Annual Meeting of the Associated-Professional-Sleep-Societies 26, pp. A47-A48. . (2003)
- 'Effect of the endogenous GPR7/8 ligand (neuropeptide W) on sleep/wakefulness'. AMER ACADEMY SLEEP MEDICINE SLEEP, CHICAGO, ILLINOIS: 17th Annual Meeting of the Associated-Professional-Sleep-Societies 26, pp. A49-A49. . (2003)
BMS1023 Chemistry & Mathematics for the Biosciences
BMS2033 Analytical Biochemistry & Chemistry
BMS2046 Pathology and Medicine
BMS3055 Pharmacology 2
BMS3064 Neuroscience 2 - Module organiser
MSc Clinical Biochemistry
Supervision of research students (BSc, MSc and PhD students)
- Divisional Representative on the Faculty of Health & Medical Sciences Ethics Committee (since 2010)
- Organiser of external (national and international) speakers for the monthly Sleep, Chronobiology & Neurodisorders Theme meetings (since 2010)
European Sleep Research Society (ESRS) - Coordinator of the ESRS forum for Women in Sleep Research
Sleep Research Society (SRS)
FENS (Federation of European Neuroscience Societies)
British Neuroscience Society (BNA)